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doi.org/10.1073/pnas.0602414103

Expression of 5-lipoxygenase and leukotriene A 4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability

..., Jesper Z. Haeggström
46
Proceedings of the National Academy of Sciences of the United States of America11.10
Volume: 103, Issue: 21, Pages: 8161 - 8166
Published: May 23, 2006
Abstract
Leukotrienes (LT) are a group of proinflammatory lipid mediators that are implicated in the pathogenesis and progression of atherosclerosis. Here we report that mRNA levels for the three key proteins in LTB 4 biosynthesis, namely 5-lipoxygenase (5-LO), 5-LO-activating protein (FLAP), and LTA 4 hydrolase (LTA4H), are significantly increased in human atherosclerotic plaque ( n = 72) as compared with healthy controls ( n = 6). Neither LTC 4...
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Paper Details
Title
Expression of 5-lipoxygenase and leukotriene A 4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
DOI
doi.org/10.1073/pnas.0602414103
Published Date
May 23, 2006
Journal
Proceedings of the National Academy of Sciences of the United States of America
Volume
103
Issue
21
Pages
8161 - 8166
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