Original paper
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
Abstract
Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used for the treatment of cancer. Despite the importance of MSAs for medical applications and basic research, their molecular mechanisms of action on tubulin and microtubules remain elusive. We determined high-resolution crystal structures of αβ-tubulin in complex with two unrelated MSAs, zampanolide and epothilone A. Both compounds were bound to the taxane...
Paper Details
Title
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
Published Date
Feb 1, 2013
Journal
Volume
339
Issue
6119
Pages
587 - 590
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Notes
History