#1Paul T. Williams(LBNL: Lawrence Berkeley National Laboratory)H-Index: 55
Background: Official guidelines from the Centers for Disease Control and Prevention and the American College of Sports Medicine state that every adult should accumulate 30 minutes or more of moderate-intensity physical activity on most, preferably all, days of the week. Objective: To examine the dose-response relationship between coronary heart disease (CHD) risk factors and vigorous exercise above the recommended minimum levels to assess whether further benefits accrue. Methods: Physician-suppl...
#1L. Röcker(Humboldt University of Berlin)H-Index: 19
#2Martin Möckel(Humboldt University of Berlin)H-Index: 46
Last. Gunga Hc(Humboldt University of Berlin)H-Index: 1
view all 4 authors...
The effects of moderate 30 min cycle ergometer exercise (aerobic metabolism ; 0.85-3.71 mmol.l -1 lactate) followed by short-term exercise at maximal capacity (anaerobic metabolism ; 5.09 to 17.75 mmol l -1 lactate) on endothelin (ET) and hemostatic variables (tissue plasminogen activator [t-PA] antigen, prothrombin fragments [F 1,2 ], thrombin-antithrombin III complex [TAT], prothrombin time and partial thromboplastin time) were investigated in 15 male healthy subjects of varying fitness levels...
Last. Johannes Mair(University of Innsbruck)H-Index: 56
view all 7 authors...
Summary Acute physical exercise induces a temporary increase in blood coagulability as well as in fibrinolysis. Only few data have been reported concerning the hemostatic system after long lasting strenuous exercise. In order to evaluate the consequences of prolonged strenuous endurance exercise on the hemostatic system, 11 athletes were examined before, immediately after as well as 24 h after the start of a 67 km mountain run. Immediately after the race we found significant increases in thrombi...
BARTSCH, P., B. WELSCH, M. ALBERT, B. FRIEDMANN, M. LEVI, and E. K. O. KRUITHOF. Balanced activation of coagulation and fibrinolysis after a 2-h triathlon. Med. Sci. Sports Exerc., Vol. 27, No. 11, pp. 1465–1470, 1995. To examine whether exercise-induced thrombin formation is accompanied by increase
Until recently, our understanding of the role of hemostatic factors in coronary artery disease was based primarily on cross-sectional studies, epidemiologic observations, and cross-cultural compari...
: Platelet activation plays an important role in the pathomechanisms of arterial vascular disorders including stroke, peripheral arterial disease (PAD), and myocardial infarction. Circulating activated platelets may be useful markers of local thrombotic events occurring in these diseases. Using flow cytometry circulating activated platelets can be detected by determining: 1. the platelets' shape change on the basis of the different light scatter properties of discocytes and spherocytes, 2. the e...
#1Jong-Shyan Wang(NCKU: National Cheng Kung University)H-Index: 32
#2C J Jen(NCKU: National Cheng Kung University)H-Index: 1
Last. H I Chen(NCKU: National Cheng Kung University)H-Index: 1
view all 6 authors...
BACKGROUNDPlatelets play an important role in the pathogenesis of cardiovascular diseases. It is also noticed that on one hand, regular exercise can reduce the risk of cardiovascular diseases, and on the other hand, vigorous exercise provokes sudden cardiac death. We therefore hypothesize that various intensities of exercise may affect platelet function differently.METHODS AND RESULTSStrenuous and moderate exercise (about 50% to 55% of peak oxygen consumption, VO2peak) on a bicycle ergometer in ...
Last. Yasuo Ikeda(Keio: Keio University)H-Index: 90
view all 9 authors...
Early reocclusion and bleeding complications are still unresolved problems in throm bolytic therapy for acute myocardial infarction (AMI). In the present study, 16 patients treated with either fibrin-specific tissue-type plasminogen activator (t-PA) or nonspecific urokinase (UK) were studied to determine the effects of thrombolytic therapy on serial hemostatic states. Hemostatic states of each patient were estimated by measuring various plasma markers at one- to two-hour intervals during the fir...
#1B. Dag(UCPH: University of Copenhagen)H-Index: 1
#2G. Gleerup(UCPH: University of Copenhagen)H-Index: 2
Last. Kaj Winther(UCPH: University of Copenhagen)H-Index: 16
view all 6 authors...
Summary. In 12 healthy young men, strenuous cycling exercise in the supine position, caused platelet aggregability to decrease and the ADP threshold to rise from 7-0 (xM resting, to 9-5 exercising (P < 0–01). At the same time, fibrinolytic activity increased markedly: euglobulin clot lysis time shortened from 178 to 68 min, PAI-1 fell from 8–91 to 5–16 IU ml-1, and t-PA rose from 0–56 to 3–95 IU ml-1, all three values were significant to P < 001. When the erect posture was assumed after lying at...
The influences of mechanical force during physical exercise on blood coagulation and fibrinolysis were investigated and the effects of sports equipment, especially shoes were also examined. As an experimental model, local mechanical vibration was applied to the palm of the hand. General coagulation parameters did not change, but fibrinolytic activity was elevated due to the tissue plasminogen activator (t-PA) released from vascular endothelial cells stimulated by vibration. The influence of mech...
ABSTRACTIntroduction: The aim of this review is to introduce the audience to exercise training (ET) as a therapeutic tool in coronary heart disease (CHD) and to discuss the role of and advances in ...
AbstractFollowing acute exercise, normotensive and hypertensive subjects both undergo changes in hemostatic and fibrinolytic properties, but the hypertensive patient’s response to exercise is exagg...
#2Jinkyung Park(GMU: George Mason University)H-Index: 2
Background: An extensive systematic review was undertaken in the current literature in order to explore the role of different types and intensities of exercise in cell adhesion molecules (CAMs), one of the markers of vascular inflammation, endothelial dysfunction, and atherosclerosis. Methods: Twenty-eight qualifying studies were extensively reviewed to examine the effects of different intensities (low-to-moderate vs. high) and types (aerobic vs. resistance) of exercise on intercellular adhesion...
#1Stefan Heber(Medical University of Vienna)H-Index: 7
#2Ivo Volf(Medical University of Vienna)H-Index: 18
As platelet activation is closely related to the liberation of growth factors and inflammatory mediators, platelets play a central role in the development of CVD. Virtually all cardiovascular risk factors favor platelet hyperreactivity and, accordingly, also physical (in)activity affects platelet function. Within this paper, we will summarize and discuss the current knowledge on the impact of acute and habitual exercise on platelet function. Although there are apparent discrepancies regarding th...
Last. Henri M. H. Spronk(Maastricht University Medical Centre)H-Index: 54
view all 4 authors...
Abstract Although regular exercise is beneficial for health, exercise-related thrombotic events, such as venous thromboembolism and myocardial infarctions, are occasionally observed. These events are characterized by a prothrombotic condition in which interactions between coagulation factors, the vessel wall and the fibrinolytic system play an important role. Apparently, various durations and intensities of exercise have different effects on haemostasis and especially high intensity exercise ten...
Last. K. J. Wardrop(WSU: Washington State University)H-Index: 4
view all 5 authors...
Summary There is evidence that equine platelet reactivity is altered by strenuous exercise. Changes in platelet reactivity could impact haemostasis following exercise-induced injury and may play a role in the pathophysiology of exercise-induced pulmonary haemorrhage. Interpretation of results of previous studies is hindered by potential in vitro-induced changes in platelet activity through the choice of anticoagulant and the use of platelet inhibitors. The present study was undertaken to re-eval...
Purpose Physical fitness may confer protection from thrombosis; however, exercise-induced platelet activation may be involved in the triggering of acute vascular events. This study aimed to assess haemostatic responses to acute exercise in trained and sedentary middle-aged subjects. Methods 21 first class Scottish football referees and 15 sedentary controls performed a treadmill exercise test. Blood sampling was performed before, immediately after and 30 minutes post-exercise. Samples were analy...
Background: Thrombin and plasmin play a central role in ongoing thrombosis and platelet activation in patients with acute ST-elevation myocardial infarction (STEMI). Data of thrombin and plasmin activity in the early course of STEMI and the relation to outcome are scarce.Methods: We included 68 consecutive patients (53 male, 59 ± 11.4 years) with STEMI who underwent acute catheter-based reperfusion therapy within the first 12 h after onset of symptoms. Blood samples were taken at admission and a...
Background: Exercise affects growth and development through a complex interaction between the endocrine, immune, and nervous systems. To date very little is known about how these systems respond to exercise in children or adolescents. Moreover, there are few studies that have examined growth factors, pro-inflammatory cytokines, and peripheral blood mononuclear cell responses to 'real-life' or field exercise solely in girls. Aim: To determine the acute exercise-induced alterations in the growth h...
