Objectives
To assess the impact on clinical management of introducing 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)-computed tomography (CT) in to the work-up of patients with primary and recurrent biliary malignancy.
With the increasing utilization of integrated positron-emission tomography/computed tomography (PET/CT) using the glucose analogue 2-[18F]-fluoro-2-deoxy- d- glucose (FDG) in oncological imaging, it is important for radiologists and nuclear medicine physicians to be aware that FDG uptake is not specific for malignancy, as many different physiological variants and benign pathological conditions can also exhibit increased glucose metabolism. Such false-positive FDG uptake often arises outside the ...
#1Sébastien Gaujoux(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 42
#2Peter J. Allen(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 97
Even after extensive preoperative assessment, staging laparoscopy may allow avoidance of non-therapeutic laparotomy in patients with radiographically occult metastatic or locally unresectable disease. Staging laparoscopy is associated with decreased postoperative pain, a shorter hospital stay and a higher likelihood of receiving systemic therapy compared to laparotomy but its yield has decreased with improvements in imaging techniques. Current uses of staging laparoscopy include the following: (...
Last. Byung Ik Kim(SKKU: Sungkyunkwan University)H-Index: 32
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Background Reports concerning the clinical usefulness of 18F 2-fluoro-2-deoxy-d-glucose integrated positron emission and computed tomography (18F-FDG PET-CT) for patients with gallbladder cancer and cholangiocarcinoma are relatively scarce. The purpose of this study was to assess the diagnostic value of PET-CT in relation to a conventional imaging modality, multidetector row CT (MDCT), for patients with gallbladder cancer and cholangiocarcinoma.
#1Matthew T. Hueman(JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
#1Matthew T. Hueman(JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
Last. Timothy M. Pawlik(JHUSOM: Johns Hopkins University School of Medicine)H-Index: 118
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Gallbladder cancer is an uncommon cancer that has traditionally been associated with a poor prognosis. In the era of laparoscopic cholecystectomy, incidental gallbladder cancer has dramatically increased and now constitutes the major way patients present with gallbladder cancer. While patients with incidental gallbladder cancer have a better survival than patients with nonincidental gallbladder cancer, incidental gallbladder cancer can be associated with a varied prognosis. Imaging with computed...
We previously reported aggregate data showing that PET was associated with a change in intended management for over one third of patients participating in the National Oncologic PET Registry (NOPR). Here, we present results for specific cancer types and indications for testing. Methods: The NOPR collected questionnaire data from referring physicians on intended management before and after PET. Data were available from 40,863 PET studies done at 1,368 centers. The impact of PET was assessed for 1...
Background The purpose of the current study was to evaluate the accuracy of 18F-FDG PET/CT in staging hilar cholangiocarcinoma. Materials and Methods From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality 18F-FDG PET/CT was performed before surgery. The report was reviewed with comparison to the operative and pathological results in each case for tumour-node-metastasis staging. Results Sevente...
Background and Aim: 18F-Fluoro-2-deoxy-d-glucose positron emission tomography (18FDG-PET) is promising for diagnosis and treatment of various malignancies. The aim of this study was to evaluate the clinical usefulness of 18FDG-PET in differential diagnosis and staging of cholangiocarcinomas according to the intrahepatic, perihilar and common bile duct lesions and to compare with computerized tomography (CT) scan. Methods: From January 2000 to September 2003, 54 patients with suspected cholangioc...
OBJECTIVES: This study was conducted to evaluate the clinical role of integrated positron emission and computed tomography (PET-CT) in patients with suspected and potentially operable cholangiocarcinoma. METHODS: Between October 2005 and May 2007, 123 patients with suspected cholangiocarcinoma were enrolled in this study after diagnostic workup, including biliary dynamic computed tomography (CT) and magnetic resonance imaging/magnetic resonance cholangiopancreatography (MRI/MRCP) with magnetic r...
#1Carlos U. Corvera(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 26
#2Leslie H. Blumgart(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 89
Last. William R. Jarnagin(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 123
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Background Although 18 F-fluorodeoxyglucose positron emission tomography (PET) has widespread clinical use, its role in cancers of the biliary tract is ill-defined. The aim of this study was to determine if preoperative PET provided additional staging information in patients with biliary tract cancer, beyond that obtained through conventional anatomic imaging. The role of PET in detecting disease recurrence after resection was also examined. Study Design Between March 2001 and October 2003, 126 ...
Last. Jeremy J. Erasmus(University of Texas MD Anderson Cancer Center)H-Index: 41
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Positron emission tomography (PET)/computed tomography (CT) has important utility and limitations in the initial staging of esophageal cancer, evaluation of response to neoadjuvant therapy, and detection of recurrent malignancy. Esophageal cancer is often treated by using a combined modality approach (chemotherapy, radiation therapy, and esophagectomy); correct integration of PET/CT into the conventional work-up of esophageal cancer requires a multidisciplinary approach that combines the informa...
Last. Karin A. Herrmann(University Hospitals of Cleveland)H-Index: 32
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OBJECTIVE The purpose of the study was to investigate the potential added value of 18F-FDG-PET/MRI (functional information derived from PET) over standard diagnostic liver MRI (excellent soft tissue characterization) in diagnosing and staging suspected primary hepatobiliary malignancies including extrahepatic cholangiocarcinoma (ECC), intrahepatic cholangiocellular carcinoma (ICC) and gallbladder cancer (GBCA). METHODS Twenty consecutive patients with suspected hepatobiliary malignancy were incl...
Gallbladder cancer is the most common malignancy of the biliary tract. It is also the most aggressive biliary tumor with the shortest median survival duration. Complete surgical resection, the only...
Last. Shunxiang Wang(Hebei Medical University)H-Index: 1
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Myopericytoma is a rare type of benign tumor, which commonly affects all four limbs. The occurrence of myopericytoma in the liver is extremely rare. Myopericytoma with a size of >1 cm in diameter in the liver has not been previously reported. Due to the limited number of cases, the preoperative diagnosis of liver myopericytoma based on laboratory and imaging examinations is difficult. In the present case report, a patient with multiple myopericytoma in the liver, with a maximum diameter of 4.5 c...
Last. Hong Joo Kim(SKKU: Sungkyunkwan University)H-Index: 32
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OBJECTIVE: We aimed to evaluate the diagnostic value and prognostic relevance of FDG positron emission tomography/computed tomography (PET-CT) in extrahepatic cholangiocarcinoma patients. MATERIALS AND METHODS: This study included 234 extrahepatic cholangiocarcinoma patients who underwent FDG PET-CT between June 2008 and February 2016. The diagnostic performance of FDG PEG-CT was compared to that of contrast-enhanced multi-detector row CT (MDCT) and MRI. Independent prognosticators for poor surv...
Last. Yongfu Xiong(North Sichuan Medical College)H-Index: 2
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Background Accurate clinical staging of patients with cholangiocarcinoma (CCA) has a significant impact on treatment decisions. In this study, we aimed to compare the diagnostic value of magnetic resonance imaging (MRI) and 18-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for staging of CCA. Methods We performed comprehensive systematic search in Web of Science (including MEDLINE) and Excerpta Medica Database for relevant diagnostic studies in accordance with th...
Fluorine-18-fluorodeoxyglucose (FDG) as a marker of exogenous glucose utilization, has been used for detecting and characterizing various malignant lesions using whole-body PET-CT imaging. FDG PET has an important role in evaluating biliary malignant tumors by differentiating tumors and detecting unsuspected distant metastasis, and therefore, providing suitable patient management. But FDG PET has a high false negative rate for infiltrating cholangiocarcinoma, and also a high false positive rate ...
Background and purpose Cholangiocarcinoma is an infrequent neoplasm barely studied with 18F-FDG–PET/CT. We evaluated the metabolic behavior of cholangiocarcinoma in PET/CT according to its location (intra or extrahepatic) and analyzed the relationship between metabolic parameters of the primary tumor and tumor markers (CA19-9 and CEA), determining their prognostic significance.
: Objective: The present study aimed to identify the clinical significance of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging in patients with occupational cholangiocarcinoma. Methods: This study included 10 men with occupational cholangiocarcinoma who were former or current workers at a printing company in Osaka, Japan. Of the 10 patients, 2 had 2 main tumors and 1 had 3 main tumors. Twelve FDG-PET imaging findings in the 10 patients could be analyzed. We evaluated...
This meta-analysis was performed to determine the diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in assessing primary cholangiocarcinoma (CCA) and CCA with lymph node and distant metastasis. A literature search for studies reporting the use of 18F-FDG-PET for preoperative work-up/staging in patients with CCA was performed. Diagnostic OR (DOR) was used as an index of diagnostic performance of FDG-PET/CT in predicting primary CCA, lymph node metastases, an...
Hepatocellular carcinoma (HCC) is the sixth most common malignancy in Asia and Africa and constitutes 70%–85% of primary liver cancers. In addition to clinical information, benign findings and pitfalls in PET/CT reading using various radiotracers, and teaching cases, this chapter reviews evidence-based recommendations regarding PET/CT examination in hepatobiliary cancers and compares them with statements in major clinical guidelines. According to evidence-based data, fludeoxyglucose (FDG) PET/CT...