Structural fat grafting: more than a permanent filler.

Published on Sep 1, 2006in Plastic and Reconstructive Surgery4.209
· DOI :10.1097/01.PRS.0000234610.81672.E7
Sydney R. Coleman14
Estimated H-index: 14
(NYU: New York University),
Sydney R. Coleman25
Estimated H-index: 25
(NYU: New York University)
Abstract Grafted fat has many attributes of an ideal filler, but the results, like those of any procedure, are technique dependent. Fat grafting remains shrouded in the stigma of variable results experienced by most plastic surgeons when they first graft fat. However, many who originally reported failure eventually report success after altering their methods of harvesting, refinement, and placement. Many surgeons have refined their techniques to obtain long-term survival and volume replacement with grafted fat. They have observed that transplanted fat not only adjusts facial and body proportion but also improves surrounding tissues into which the fat is placed. They have noted not only the improvement in the quality of aging skin and scars but also a remarkable improvement in conditions such as radiation damage, chronic ulceration, breast capsular contracture, and damaged vocal cords. The mechanism of fat graft survival is not clear, and the role of adipose-derived stem cells and preadipocytes in fat survival remains to be determined. Early research has indicated the possible involvement of more undifferentiated cells in some of the observed effects of fat grafting on surrounding tissues. Of particular interest is the research that has pointed to the use of stem cells to repair and even to become bone, cartilage, muscle, blood vessels, nerves, and skin. Further studies are essential to understand grafted fat tissue.
📖 Papers frequently viewed together
683 Citations
755 Citations
232 Citations
#1Gino Rigotti (Polytechnic University of Milan)H-Index: 17
#1Gino Rigotti (Polytechnic University of Milan)H-Index: 7
Last. Andrea SbarbatiH-Index: 59
view all 8 authors...
Background: There is evidence that stern cells contribute to the restoration of tissue vascularisation and organ function. The objective of this study was to assess the presence of adipose derived adult stern cells left in their natural scaffold in the purified lipoaspirate and to access the clinical effectiveness of lipoaspirate transplantation in the treatment of radiation side effects. Methods: This study was designed beginning with surgical procedures in 2002 and envisaging a continious pati...
1,241 CitationsSource
Resume Le transfert de tissu adipeux est une technique ancienne. Depuis sa premiere utilisation en 1893, il a ete utilise dans de nombreuses indications. Cependant, apres plus d'un siecle d'evolution, il n'existe pas aujourd'hui de technique princeps du transfert d'adipocytes admise par tous. En effet, multiples sont les variations techniques decrites dans la litterature. Elles ont toutes ete proposees dans le seul but de diminuer la resorption de la graisse transferee. Aujourd'hui, le principal...
53 CitationsSource
#1Farshid Guilak (Duke University)H-Index: 120
#2Kristen E. Lott (Duke University)H-Index: 1
Last. Jeffrey M. Gimble (Pennington Biomedical Research Center)H-Index: 86
view all 7 authors...
Pools of human adipose-derived adult stem (hADAS) cells can exhibit multiple differentiated phenotypes under appropriate in vitro culture conditions. Because adipose tissue is abundant and easily accessible, hADAS cells offer a promising source of cells for tissue engineering and other cell-based therapies. However, it is unclear whether individual hADAS cells can give rise to multiple differentiated phenotypes or whether each phenotype arises from a subset of committed progenitor cells that exi...
623 CitationsSource
#1Hironori Nakagami (Osaka University)H-Index: 52
#2Kazuhisa MaedaH-Index: 22
Last. Yasufumi KanedaH-Index: 108
view all 11 authors...
Objective— The delivery of autologous progenitor cells into ischemic tissue of patients is emerging as a novel therapeutic option. Here, we report the potential impact of cultured adipose tissue–derived cells (ADSC) on angiogenic cell therapy. Method and Results— ADSC were isolated from C57Bl/6 mouse inguinal adipose tissue and showed high expression of Sca I and CD44, but not c-kit, Lin, CD34, CD45, CD11b, and CD31, compatible with that of mesenchymal stem cells from bone marrow. In coculture c...
742 CitationsSource
Background. A careful look at the aging face shows it to consist of more than loose skin and rhytids. With aging, the face loses its anterior projection, with a resultant displacement of skin inferiorly. There is mimetic muscular accentuation and an abundance of deep grooves and shadows. In addition, fat redistributes in specific patterns in overweight versus lean individuals. Objective. To restore the three-dimensional projection and overall shape of the face to more youthful contours and to el...
26 CitationsSource
#1Gordon M. Riha (BCM: Baylor College of Medicine)H-Index: 7
#2Peter H. Lin (BCM: Baylor College of Medicine)H-Index: 61
Last. Changyi Chen (BCM: Baylor College of Medicine)H-Index: 71
view all 5 authors...
As the prevalence of vascular disease has continued to expand, the need for a suitable arterial replacement has prompted researchers to look beyond synthetic and autologous grafts toward the field of tissue engineering. Advances in vascular tissue engineering have utilized both mesenchymal and hematopoietic stem cells as a cell source in an attempt to create a fully engineered small-diameter graft. Stem cells offer enormous potential as a cell source because of their proliferative and growth pot...
145 CitationsSource
#1Timm P. Wolter (RWTH Aachen University)H-Index: 11
#2Dennis von HeimburgH-Index: 18
Last. Norbert PalluaH-Index: 62
view all 5 authors...
Abstract:Cryopreservation of fat grafts for autologous fat transplantation renders repeated harvesting procedures unnecessary. Anecdotic reports have been published, yet data about adipocyte survival are sparse. The beneficial effect of added cryoprotective agents (CPA) is known from other tissues b
115 CitationsSource
#1Yehuda Ullmann (Technion – Israel Institute of Technology)H-Index: 30
#2Oren Shoshani (Technion – Israel Institute of Technology)H-Index: 15
Last. Amos Gilhar (Technion – Israel Institute of Technology)H-Index: 34
view all 7 authors...
Background. The use of suctioned fat grafts for correction of soft tissue defects is a widespread procedure in esthetic and reconstructive surgery. The main disadvantage of this simple and sensible procedure is the unpredictable absorption rate of the fat graft. A lot of research has been performed aiming for enhancement of the take of the fat grafts. Objective. Our study was performed to find if there is any favorable donor site for fat harvesting. Methods. This in vivo experiment using the nud...
111 CitationsSource
#1Brian M. Strem (UCLA: University of California, Los Angeles)H-Index: 4
#2Kevin C. Hicok (Cytori Therapeutics Inc)H-Index: 4
Last. Marc H. Hedrick (UCLA: University of California, Los Angeles)H-Index: 23
view all 8 authors...
Tissue engineering offers considerable promise in the repair or replacement of diseased and/or damaged tissues. The cellular component of this regenerative approach will play a key role in bringing these tissue engineered constructs from the laboratory bench to the clinical bedside. However, the ideal source of cells still remains unclear and may differ depending upon the application. Current research for many applications is focused on the use of adult stem cells. The properties of adult stem c...
1,142 CitationsSource
Last. José Antonio Rodríguez-Montes (UAM: Autonomous University of Madrid)H-Index: 10
view all 6 authors...
PURPOSE: The effective management of fistulas in patients with Crohn's disease presents an extremely challenging problem. Mesenchymal adult stem cells extracted from certain tissues, such as adipose tissue, can differentiate into various cell types. Therefore, we have tried to use such cells to stimulate healing of Crohn's fistulas. METHODS: We designed a prospective Phase I clinical trial, involving five patients with Crohn's disease, to test the feasibility and safety of autologous stem cells ...
734 CitationsSource
Cited By1054
#1Francesco M. EgroH-Index: 11
Last. Sydney R. ColemanH-Index: 3
view all 0 authors...
Abstract null null Liposuction and liposculpture represent the evolution of minimally invasive plastic surgery techniques developed in an attempt of restoring shape and form. This chapter critically appraises each step in the process of liposuction and fat grafting, from harvesting to processing to injecting, to provide a detailed overview for the surgeon of the 21st century.
#1Mengfan Wu (Brigham and Women's Hospital)
#2Mehran Karvar (Brigham and Women's Hospital)H-Index: 3
Last. Adriana C. Panayi (Brigham and Women's Hospital)H-Index: 9
view all 0 authors...
Abstract null null Background: Autologous fat grafting is a popular technique for soft-tissue augmentation, but the fat survival rate is unpredictable. Platelet-rich plasma (PRP) has emerged as an null new null adjuvant to enhance fat graft survival. null Objectives: This null systematic null literature review and meta-analysis aimed to investigate the effect of PRP on the survival rate of fat grafting. null Methods: A comprehensive systematic literature search was done to identify clinical stud...
#1Zhifang Zheng (Southern Medical University)H-Index: 3
Last. Wenhua Huang (Southern Medical University)H-Index: 22
view all 6 authors...
BACKGROUND East Asian faces vary in shape but only oval faces seem to be considered attractive. Many patients with wide faces seek removal of part of the mandibular angle and/or zygoma to achieve an ideal facial contour, but the procedure is high risk and the recovery period is relatively protracted. OBJECTIVES We sought to achieve ideal facial contours through the use of autologous fat grafting (AFG) combined with masseter botulinum toxin (BTX) injection for patients with wide faces and massete...
#1Benjamin B Scott (Harvard University)H-Index: 4
#1Benjamin B Scott (Harvard University)
Last. William G. Austen (Harvard University)H-Index: 65
view all 3 authors...
#1Peng-ju Fan (CSU: Central South University)H-Index: 2
#2Man Fang (CSU: Central South University)H-Index: 1
Last. Shaorong Lei (CSU: Central South University)H-Index: 4
view all 9 authors...
BACKGROUND A low survival rate is one of the main challenges in fat grafting. OBJECTIVES This study aimed to evaluate whether the microfat obtained using a novel strategy promoted the survival and retention of fat grafts. METHODS A 5 mm diameter blunt tip cannula with larger side holes (~30 mm 2 per hole) was used to obtain macrofat. Subsequently, a novel strategy based on a newly invented extracorporeal cutting device was used to cut the macrofat into microfat, which was named adipose-derived p...
#1Debra A. Bourne (University of Pittsburgh)H-Index: 6
#2Jacqueline M. Bliley (University of Pittsburgh)H-Index: 12
Last. J. Peter RubinH-Index: 60
view all 14 authors...
OBJECTIVE: This study aimed to prospectively assess outcomes for surgical autologous fat transfer (AFT) applied for traumatic and postsurgical craniofacial deformities. The minimally invasive nature of AFT has potential for reduced risk and superior outcomes compared with current reconstructive options. BACKGROUND: Craniofacial deformities have functional and psychosocial sequelae and can profoundly affect quality of life. Traditional reconstructive options are invasive, invasive, complex, and o...
2 CitationsSource
Body contouring procedures are highly impactful because of their potential to improve a patient's quality of life. These procedures, particularly when performed on patients following massive weight loss, may require secondary intervention to treat residual contour abnormalities. Presently, there is a paucity of information in the literature detailing the avoidance and correction of body contouring deformities. Herein, we will discuss the management of patients seeking revisional body contouring ...
#1Qiang Dai (Peking Union Medical College)
#2Qian Yu (Peking Union Medical College)
Last. Lei Cai (Peking Union Medical College)
view all 4 authors...
BACKGROUND Once an early-stage immature scar develops into a hypertrophic scar, it is difficult to achieve satisfactory improvement with existing treatments. Therefore, the prevention of hypertrophic scar formation should be given priority. Fat grafting was previously proven to be an effective treatment for mature scars, but it has not been used in the early-stages of (less than three months) scar formation. OBJECTIVES We present our experience with the use of combined grafting of macro fat and ...
#1Peng-cheng Liu (Sichuan University)H-Index: 2
#2Qiuwen Tan (Sichuan University)H-Index: 8
Last. Qing Lv (Sichuan University)H-Index: 14
view all 10 authors...
Lipofilling is a popular technique for soft tissue augmentation, limited by unpredictable graft survival. This study aimed at exploring the effect of hydrogel from acellular porcine adipose tissue (HAPA) on angiogenesis and survival of adipose tissue used for lipofilling. The effect of HAPA on adipose-derived stem cells (ADSCs) proliferation, adipogenic differentiation, and vascular endothelial growth factor (VEGF) secretion were evaluated in hypoxia and normoxia in vitro. For the in vivo study,...
BACKGROUND Craniofrontonasal dysplasia (CFND) is a rare congenital craniofacial syndrome characterized by single suture synostosis, hypertelorism, other clinical facial features, and abnormalities in the upper extremities. There are only a few studies in the applicable literature that address hypertelorism management for CFND patients and outcomes and complication rates. METHODS A retrospective study was performed on consecutive late presenting CFND patients referred to our hospital with substan...