Pathology Produced by Sulfur Mustard in Human Skin Grafts on Athymic Nude Mice. I. Gross and Light Microscopic Changes

Sulfur mustard (SM) is a powerful vesicant in humans whose pathogenic mechanism is not well understood and an agent for which no effective therapy exists. We selected human skin grafted to congenitally athymic nude mice to study SM-induced injury because the injury in various animal models differs from skin injury in humans. Grafts made from full-thickness human neonatal foreskin or from partial-thickness adult facial, mammary, and abdominal...