Original paper

Augmentation of allergic inflammation in prostanoid IP receptor deficient mice

Volume: 137, Issue: 3, Pages: 315 - 322
Published: Oct 1, 2002
Abstract
To evaluate the role of prostaglandin I 2 (PGI 2 ) in allergic inflammation, allergic responses in the airway, skin and T cells were studied in mice lacking the receptor for PGI 2 (the prostanoid IP receptor) through gene disruption. Three inhalations of antigen caused an increase in plasma extravasation, leukocyte accumulation and cytokine (interleukin (IL)‐4 and IL‐5) production in the airway of sensitized mice. These airway inflammatory...
Paper Details
Title
Augmentation of allergic inflammation in prostanoid IP receptor deficient mice
Published Date
Oct 1, 2002
Volume
137
Issue
3
Pages
315 - 322
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