Augmentation of allergic inflammation in prostanoid IP receptor deficient mice

To evaluate the role of prostaglandin I 2 (PGI 2 ) in allergic inflammation, allergic responses in the airway, skin and T cells were studied in mice lacking the receptor for PGI 2 (the prostanoid IP receptor) through gene disruption. Three inhalations of antigen caused an increase in plasma extravasation, leukocyte accumulation and cytokine (interleukin (IL)‐4 and IL‐5) production in the airway of sensitized mice. These airway inflammatory...