Use of autologous serum eyedrops for the treatment of ocular surface disease: first US experience in a large population as an insurance-covered benefit.

Published on Dec 1, 2012in Archives of Ophthalmology
· DOI :10.1001/ARCHOPHTHALMOL.2012.1652
Cyril A. Dalmon3
Estimated H-index: 3
(UCSF: University of California, San Francisco),
Naveen S. Chandra1
Estimated H-index: 1
(KP: Kaiser Permanente),
Bennie H. Jeng14
Estimated H-index: 14
(UCSF: University of California, San Francisco)
Sources
Abstract
📖 Papers frequently viewed together
317 Citations
20092.21Cornea
108 Citations
20042.46Eye
81 Citations
References6
Newest
#1Bennie H Jeng (Cleveland Clinic)H-Index: 4
#1Bennie H Jeng (Cleveland Clinic)H-Index: 1
Last. William J. DuppsH-Index: 25
view all 2 authors...
Purpose:To evaluate the success rate of treating persistent corneal epithelial defects using 50% autologous serum eyedrops.Methods:We reviewed the medical records of all patients seen at our institution from September 2004 to May 2007 who had persistent corneal epithelial defects that were nonrespon
108 CitationsSource
#1Graham A. Lee (UQ: University of Queensland)H-Index: 21
#2Simon X ChenH-Index: 2
Purpose: To evaluate the efficacy and safety of long-term application of autologous serum eye drops treating recalcitrant dry eye syndrome. Methods: A retrospective chart review was conducted of patients who had serum eye drops between May 2001 and March 2006. The clinical data collected included sex, age, indications for serum eye drops, frequency of lubricant eye drops use before and after serum eye drop treatment, Schirmer tear function test with anaesthesia, fluorescein staining at baseline ...
35 CitationsSource
#1Takashi Kojima (Tokyo Dental College)H-Index: 32
#2Reiko Ishida (Tokyo Dental College)H-Index: 15
Last. Kazuo Tsubota (Tokyo Dental College)H-Index: 120
view all 7 authors...
Purpose To evaluate the effectiveness of the autologous serum eyedrops in the treatment of severe dry eye patients. Design Prospective randomized case-control study. Methods Thirty-seven eyes of twenty severe dry eye patients without punctal occlusion were enrolled in this study. After 2 weeks of washout, they were randomly assigned to two groups. Group A patients used only preservative-free artificial tears, and group S patients used only autologous serum eyedrops. We evaluated the results of S...
191 CitationsSource
#1Bruce A. NobleH-Index: 11
#2Raymond S K Loh (LGI: Leeds General Infirmary)H-Index: 4
Last. S Quereshi (LGI: Leeds General Infirmary)H-Index: 1
view all 9 authors...
Aims: To evaluate the efficacy of 50% autologous serum drops against conventional treatment in ocular surface disorders refractory to normal treatments in a prospective randomised crossover trial. Method: Patients fulfilling ophthalmological and haematological entry criteria were randomised to either 3 months of autologous serum 50% followed by 3 months of their conventional treatment, or 3 months of conventional treatment, followed by 3 months of autologous serum. Clinical assessments, includin...
226 CitationsSource
#1Napaporn Tananuvat (University of Melbourne)H-Index: 6
#2Mark DaniellH-Index: 28
Last. Hugh R. TaylorH-Index: 123
view all 7 authors...
Purpose. To determine the efficacy and safety of topical autologous serum as a treatment of dry eye patients. Methods. A 2-month, prospective, single-masked, placebo-controlled study was conducted in patients with bilateral severe dry eye. One eye was randomized to receive the patient's own serum as a tear substitute, and the fellow eye received unpreserved normal saline solution as a placebo. Subjective symptoms and clinical parameters of dry eye including conjunctival impression cytology were ...
146 CitationsSource
#1Robert A. RalphH-Index: 1
#2Marshall G. DoaneH-Index: 18
Last. Claes H. DohlmanH-Index: 70
view all 3 authors...
• The continuous delivery of fluids to the ocular surfaces of 12 patients, for a collective total of 1,500 days, was achieved by means of a mobile perfusion pump. One patient used this device intermittently for a total of 2½ years. Severe dry-eye symptoms were ameliorated in each patient by the constant perfusion. In various situations, the following perfusion fluids have been tried: commercial balanced salt solution, commercial artificial tear solutions, acetylcysteine, and autologous and homol...
56 CitationsSource
Cited By13
Newest
The corneal functions (transparency, refractivity and mechanical strength) deteriorate in many corneal diseases but can be restored after corneal transplantation (penetrating and lamellar keratoplasties). However, the global shortage of transplantable donor corneas remains significant and patients are subject to life-long risk of immune response and graft rejection. Various studies have shown the differentiation of multipotent mesenchymal stem cells (MSCs) into various corneal cell types. With t...
22 CitationsSource
#1I-Hsin Ma (NTU: National Taiwan University)H-Index: 2
#2Lily Wei Chen (NTU: National Taiwan University)H-Index: 4
Last. Wei-Li Chen (NTU: National Taiwan University)H-Index: 22
view all 6 authors...
PURPOSE: Autologous serum eye drops are considered safe and efficient for the treatment of various ocular surface disorders, including dry eye diseases (DED) caused by the primary and secondary Sjogren syndrome (SS). However, the serum components in patients of SS may be different from those of normal patients and can thus lead to unpredictable therapeutic effects. This study divided the SS patients into active and inactive types based on the erythrocyte sedimentation rate and the presence or ab...
10 CitationsSource
#1Lyndon Jones (UW: University of Waterloo)H-Index: 69
#2Laura E Downie (University of Melbourne)H-Index: 20
Last. Jennifer P. Craig (University of Auckland)H-Index: 9
view all 16 authors...
Abstract The members of the Management and Therapy Subcommittee undertook an evidence-based review of current dry eye therapies and management options. Management options reviewed in detail included treatments for tear insufficiency and lid abnormalities, as well as anti-inflammatory medications, surgical approaches, dietary modifications, environmental considerations and complementary therapies. Following this extensive review it became clear that many of the treatments available for the manage...
373 CitationsSource
#1Amir A. Azari (Wills Eye Institute)H-Index: 9
#2Remzi Karadag (Wills Eye Institute)H-Index: 1
Last. Mark B. Juckett (UW: University of Wisconsin-Madison)H-Index: 24
view all 9 authors...
AbstractPurpose: To evaluate the treatment of autologous serum eye drops (ASED) on dry eyes in patients with graft-versus-host disease (GVHD).Methods: A retrospective chart review of 35 patients with a history of ocular GVHD following hematopoietic stem cell transplantation that used ASED to alleviate dry eye symptoms was performed. Patients were categorized into three different groups. If patients had available ophthalmic data before and after starting treatment was group 1 (n = 14), had availa...
6 CitationsSource
#1Kaevalin Lekhanont (MU: Mahidol University)H-Index: 3
Last. Varintorn ChuckpaiwongH-Index: 7
view all 4 authors...
Several studies found that 50–100% serum eye drops provided greater benefits without inducing detrimental effects on the corneal epithelial healing. This study assessed the efficacy of undiluted serum eye drops for the treatment of persistent corneal epithelial defects (PED). A total of 109 eyes received 100% serum eye drops for PED were recruited into this study. The data were compared with an historical control group of 79 eyes with PED who received conventional treatments from 2006–2011 at th...
8 CitationsSource
#1Nishant G. Soni (UMB: University of Maryland, Baltimore)H-Index: 6
#2Bennie H. Jeng (UMB: University of Maryland, Baltimore)H-Index: 14
Human serum-derived and plasma-derived therapies have become increasingly popular in the treatment of ocular surface disorders, with mounting clinical and scientific evidence suggesting good safety and efficacy profiles. These therapies may be considered for various ocular surface conditions, such as dry eye syndrome and persistent epithelial defect, when conservative management does not suffice. The costly and inconvenient process of obtaining the blood-derived products is the barrier to their ...
42 CitationsSource
#1Ryan NugentH-Index: 1
#2Graham A. Lee (UQ: University of Queensland)H-Index: 21
There is a wide spectrum of blood-derived products that have been used in many different medical and surgical specialties with success. Blood-derived products for clinical use can be extracted from autologous or allogeneic specimens of blood, but recombinant products are also commonly used. A number of blood derivatives have been used for a wide range of ocular conditions, from the ocular surface to the retina. With stringent preparation guidelines, the potential risk of transmission of blood-bo...
20 CitationsSource
Abstract To examine the evidence for the role of autologous serum eye drops (ASD) in disease of the ocular surface. A search of the literature published through May 2014 using PubMed, the ISI Web of Knowledge database, and the Cochrane Library was performed. Qualified articles were selected after review of titles, abstracts, and references. There was a significant improvement in either symptoms or some of the clinical examination findings, including tear breakup time, corneal staining, Schirmer ...
25 CitationsSource
#1Maria Rosaria De Pascale (Seconda Università degli Studi di Napoli)H-Index: 9
#2Linda Sommese (Seconda Università degli Studi di Napoli)H-Index: 19
Last. Claudio Napoli (Seconda Università degli Studi di Napoli)H-Index: 88
view all 4 authors...
Abstract Prior preclinical and clinical studies support the use of platelet-derived products for the treatment of soft and hard tissue lesions. These regenerative effects are controlled by autocrine and paracrine biomolecules including growth factors and cytokines contained in platelet alpha granules. Each growth factor is involved in a phase of the healing process, such as inflammation, collagen synthesis, tissue granulation, and angiogenesis collectively promoting tissue restitution. Platelet ...
100 CitationsSource
#1Munira Hussain (UM: University of Michigan)H-Index: 26
#2Roni M. Shtein (Visual Sciences)H-Index: 24
Last. Shahzad I. Mian (Visual Sciences)H-Index: 22
view all 7 authors...
Abstract The aim of this study was to describe the outcomes of 50% autologous serum (AS) eye drops after long-term use in a large cohort of patients with dry eyes. A retrospective cohort study was conducted on all patients treated with 50% AS eye drops at our institution between June 2008 and January 2013. Records were reviewed for clinical history, systemic risk factors, dry eye etiology, patients' symptoms, and adverse events. Ocular surface evaluation included Schirmer testing with topical an...
43 CitationsSource