FGF-2 Dimerization Involvement in Growth Factor Mediated Cell Proliferation but Not Cell Differentiation

Dimerization is a prerequisite for many growth factors in their receptor activation leading to cellular response. FGF-1 and FGF-2, members of the Fibroblast Growth Factor (FGF) family, were shown to form non-covalent dimers and oligomersin vitro.Using the two-hybrid system as anin vivobinding assay we show here that of three representative members of the FGF family, only FGF-2 is able to homodimerize. Moreover the FGF-2 isoforms could...