Mechanisms of cardiac dysfunction in obstructive sleep apnea
Abstract
Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality, largely as a result of myocardial anomalies. Numerous mechanisms cause OSA-related myocardial damage. The majority are initiated as a result of OSA-induced, chronic, intermittent hypoxia. The most-important mechanisms that lead to myocardial damage are increased sympathetic activity, endothelial dysfunction, systemic inflammation, oxidative stress, and...
Paper Details
Title
Mechanisms of cardiac dysfunction in obstructive sleep apnea
Published Date
Sep 25, 2012
Journal
Volume
9
Issue
12
Pages
679 - 688
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