: Although utility of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has been rehearsed in large vessel vasculitides, it is not known if small vessel vasculitides are also associated with increased FDG uptake. Hereby described is a 64-year-old female patient with prolonged fever and splenomegaly, which was depicted as a hot area in FDG-PET. Splenectomy disclosed microaneurysms, giant cell granuloma, perivascular leukocytic infiltration with fibrinoid necrosis, consistent with granulomatous angitis. Serum myeloperoxidase-antineutrophil cytoplasmic antibody was positive. The present case illustrates that vasculitides affecting small vessels present increased FDG uptake as do those affecting large vessels.
A 60-year-old male was referred for a positron emission tomography (PET) scan using F-18 fluoro-2-deoxyglucose (F-18 FDG) for evaluation of a right lung opacity identified on a computed tomography (CT) scan. The patient also had a history of idiopathic myelofibrosis. The PET scan revealed markedly increased uptake throughout the spleen and liver, which were massively enlarged. There was also significantly increased uptake diffusely throughout the bone marrow. These findings are a reflection of t...
Nuclear medicine plays an important role in the evaluation of infection and inflammation. Fluorine 18 fluorodeoxyglucose (FDG) is a readily available radiotracer that offers rapid, exquisitely sensitive high-resolution tomography. In patients with acquired immunodeficiency syndrome, FDG positron emission tomography (PET) accurately helps localize foci of infection and is particularly useful for differentiating central nervous system lymphoma from toxoplasmosis. FDG PET can also help localize the...
A 63-year-old woman with a history of anemia resulting from β-thalassemia minor was referred for whole-body positron emission tomography (PET) with F-18-FDG. She had a provisional diagnosis of pulmonary malignancy or lymphoma. PET showed moderate, diffuse F-18 FDG uptake in both lungs in a pattern consistent with inflammation and also splenomegaly with homogeneously increased FDG uptake. Biopsy of the pulmonary lesions revealed a diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) ...
Wegener's granulomatosis is a necrotizing granulomatous vasculitis that mainly affects the upper airways, lungs, and kidneys. Autoimmune mechanisms are hypothesized to play a role in the pathophysiology of the disease. F-18 fluorodeoxyglucose-positron emission tomographic scanning is normally used to differentiate benign from malignant disease as a result of differences in glucose metabolism. The authors present a case of Wegener's granulomatosis in which F-18 fluorodeoxyglucose-positron emissio...
Last. Luc Mortelmans(Katholieke Universiteit Leuven)H-Index: 76
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We describe the diagnostic contribution of [ 18 F]fluoro-deoxyglucose (FDG) positron emission tomography (PET) scan in 58 consecutive cases of fever of unknown origin (FUO) and compare this new approach with gallium scintigraphy. This investigation was performed from March 1996 through October 1998 at Gasthuisberg University Hospital in Leuven, Belgium. A final diagnosis was established for 38 patients (64%). Forty-six FDG-PET scans (79%) were abnormal; 24 of these abnormal scans (41% of the tot...
Last. Richard L. Wahl(UM: University of Michigan)H-Index: 113
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Using PET, we investigated the change in 18 F-fluorordeoxyglucose (FDG) uptake in the spleen after granulocyte colony-stimulating factor (G-CSF) treatment. Methods: Forty-two FDG PET scans in 12 patients with locally advanced breast cancer who received G-CSF treatment were studied (12 baseline, 10 during G-CSF, 20 after G-CSF treatment). The PET images obtained at 50-60 and 60-70 min after intravenous FDG (370 MBq) injection were assessed visually and were compared with those before G-CSF treatm...
The rare clinicopathological entity ‘disseminated visceral giant cell arteritis’ (DVGCA) was first described in 1978. It is characterized by widespread small-vessel giant cell angitis and extravascular granulomas. A normal and healthy 7-month-old boy who presented unexpectedly with sudden infant death syndrome (SIDS) is reported. Histological examination at autopsy revealed giant cell angitis of the aorta, common carotid, coronary, pulmonary, celiac, mesenteric and common iliac arteries. There w...
We report a unique case of early-phase Takayasu arteritis in which the vessels demonstrated accumulation of [ 18 F]fluorodeoxyglucose (FDG) on PET scanning. This observation suggests the possible use of FDG-PET for the diagnosis of vasculitis. Early diagnosis of Takayasu arteritis may permit early treatment and possibly could prevent progression to the occlusive or pulseless phase of this disease.
Fluorine-18-2-deoxy-24-fluoro-D-glucose ([ 18 F]FDG) uptake and distribution in an experimentally induced inflammatory tissue were investigated. Methods : Rats were subcutaneously inoculated with turpentine oil to induce inflammation and used for tissue distribution studies and autoradiography. Results : Time course study of [ 18 F]FDG tissue distribution showed that the uptake in inflammatory tissue increased gradually until 60 min and then decreased. A longitudinal study of [ 18 F]FDG tissue d...
A previously well 48-year-old male patient presented with several months of weight loss, fever, massive hepatosplenomegaly, and pancytopenia. A provisional diagnosis of lymphoma could not be confirmed on blind lymph node or bone marrow biopsies. Referral for 18F-FDG PET was made to identify an appropriate biopsy site. Focal uptake in multiple splenic lesions was seen, with normal FDG uptake elsewhere in the body. Splenectomy was then performed and histology revealed leishmaniasis, with no eviden...
Romatolojik hastal›klar›n erken donemde tespitinin te- davi baflar›s› ac›s›ndan son derece onemli olduu bilinmek- tedir. Ancak hastal›¤›n nonspesifik klinik bulgularla (atefl, kilo kayb›, akut faz yukseklii gibi) ortaya c›kabilmesi, tan› koydurucu bulgular›n gec donemde saptanabilmesi ve la- boratuvar testlerinin yetersizlii gibi nedenlerle erken tan› guc olabilmektedir. Ayr›ca mevcut belirteclerin azl›¤› ne- deniyle tan› sonras› tedavi cevab›n›n izlenmesinde de s›k›n- t› oluflabilmektedir. Hast...
Aim: Diffuse splenic 18F-Fluorodeoxyglucose (FDG) uptake has shown to be associated with concurrent inflammation. We evaluated the prognostic value of diffuse splenic FDG uptake for predicting prognosis in cholangiocarcinoma patients. Patients, methods: Sixty-four patients with unresectable cholangiocarcinoma performed Positron emission tomography/computed tomography (PET/CT) using FDG between July 2009 and April 2012. Patients were divided into two groups according to splenic FDG uptake relativ...
OBJECTIVES: Concurrent inflammation or anemia at the time of PET/computed tomography (CT) could be one of several causes of diffuse splenic (18)F-fluorodeoxyglucose ((18)F-FDG) uptake. In this study, we focused on cytokines to investigate interactions during this phenomenon and clarify the significance of splenic (18)F-FDG uptake in PET/CT. METHODS: We selected 40 patients (17 women and 23 men) with cholangiocarcinoma, pancreatic cancer, or gallbladder cancer who had undergone PET/CT. These pati...
Methods A retrospective review identified consecutive records of patients with IS who underwent F-18 FDG positron emission tomography – computed tomography scans between January 2007 and July 2008 and recruited 23 patients (57.8 ± 15.6 years, range: 20–81 years, eight men, 15 women) and their hematological laboratory data. The regions of interest were used to measure the maximum standardized uptake value (SUVmax) for the bone marrow (BM), liver, and spleen in each patient. We calculated the sple...
Resumen Mujer de 51 anos con fiebre elevada, astenia y perdida de peso de 3 semanas de evolucion. Antecedente de carcinoma de mama y metastasis hepatica. La exploracion fisica demostro pequenas adenopatias no dolorosas en ambas cadenas latero cervicales. El analisis de sangre registro 9.200 leucocitos con 69% de linfocitos y elevacion de enzimas hepaticas. Las determinaciones serologicas asi como los hemocultivos y urocultivos fueron negativos, siendo unicamente positiva la determinacion de IgM ...
Objective: The purpose of this study was to investigate correlations between diffuse splenic FDG uptake and hematological and inflammatory parameters to clarify the significance of splenic FDG uptake on PET/CT images. Methods: We retrospectively analyzed the consecutive records of F-18 FDG PET/CT scans and selected 31 patients with diffuse splenic FDG uptake as patient group. A total of 25 patients who underwent F-18 FDG PET/CT scans for simple health checkup were enrolled as control group. ROIs...
Resume La scintigraphie au 18fluorodeoxyglucose (18FDG) ou tomographie par emission de positrons (TEP) est un moyen d’imagerie metabolique non invasive qui permet d’evaluer l’activite et l’etendue des arterites des troncs de gros calibre. Elle est d’un apport diagnostique majeur dans la maladie de Horton (surtout ses presentations systemiques), la maladie de Takayasu et les aortites inclassables. Son aptitude a detecter les phases les plus precoces de l’inflammation de la paroi vasculaire pourra...
Early diagnosis is crucial for effective treatment of Wegener’s granulomatosis, although this disease shows only atypical symptoms in the primary stage. This report describes a patient suspected of having a malignancy based on integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), which showed increased uptake in pulmonary nodules and nasopharyngeal mucosa. Integrated PET/CT is therefore considered to be useful to confirm the distribution and determine the o...
Abstract The case of a 51 years-old woman with high fever, asthenia and weight loss of three weeks of evolution is presented. She had a personal history of breast cancer and liver metastases. The physical examination showed small painless enlarged lymph nodes in both latero-cervical chains. The blood analysis showed 9200 leukocytes with 69% of lymphocytes and elevated liver enzymes. Serological determinations as well as repeated blood and urine culture were negatives, only the anti-CMV IgM deter...