GW24-e3174 A trial overexpression of ACE2 improves the canine rapid atrial pacing-induced structural remodelling

Objectives

Atrial fibrillation (AF) is associated with significant morbidity and mortality. Substantial evidence suggests that the renin angiotensin system (RAS) has a role in the pathogenesis of AF. Angiotensin-converting enzyme 2 (ACE2), a monocarboxypeptidase capable of metabolising angiotensin II (Ang II) into angiotensin-(1-7) [Ang-(1-7)], has emerged as a potential therapeutic target. The purpose of this study was to investigate...