Heart
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#1Surendra Kumar Naik (AIIMS: All India Institute of Medical Sciences)
#2Raghav Bansal (AIIMS: All India Institute of Medical Sciences)H-Index: 2
Last. Gautam Sharma (AIIMS: All India Institute of Medical Sciences)H-Index: 11
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A hypertensive old man in his 80s with no other known comorbidities presented with exertional fatigue for 3 months and an episode of presyncope 2 days prior to presentation. Bradycardia (heart rate of 45/min) was detected during blood pressure measurement, and a 12-lead ECG revealed 2:1 atrioventricular block with complete right bundle branch block (RBBB) and normal PR interval on conducted beats (figure 1A). Echocardiography demonstrated a structurally normal heart. In view of probable infrahis...
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#1Andrea Girnius (University of Cincinnati Academic Health Center)H-Index: 1
#2Dominica Zentner (University of Melbourne)H-Index: 12
Last. Gruschen R. VeldtmanH-Index: 33
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Background/objectives: Pregnancy may potentiate the inherent hypercoagulability of the Fontan circulation, thereby amplifying adverse events. This study sought to evaluate thrombosis and bleeding risk in pregnant women with a Fontan. Methods: We performed a retrospective observational cohort study across 13 international centres and recorded data on thrombotic and bleeding events, antithrombotic therapies and pre-pregnancy thrombotic risk factors. Results: We analysed 84 women with Fontan physio...
1 CitationsSource
#1Catherine M Otto (UW: University of Washington)H-Index: 85
Aortic stenosis (AS) is common in the elderly with an increasing number of patients as our population ages but precise estimates of prevalence have been limited by inadequate diagnostic data in most clinical databases. In this issue of Heart , Owens and colleagues1 performed a targeted review of medical records for 5795 participants over age 65 years in the population based Cardiovascular Health Study to determine the frequency of moderate to severe AS. Over 25 years, the cumulative frequency of...
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A woman in her 70s presented with acute right arm paresis. Her medical history was significant for diabetes mellitus, hypertension, dyslipidaemia and hypothyroidism, all well controlled with medication. For the previous 2 months she had fibromyalgia for which pregabalin 50 mg per day was prescribed with little improvement. Her ECG showed non-specific ST-T abnormalities, the high sensitivity cardiac troponin I (hs-cTnI) was moderately elevated and an increased eosinophil blood count (EBC) of 2.2 ...
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#1Michael Drozd (University of Leeds)H-Index: 8
#2Samuel D. Relton (University of Leeds)H-Index: 8
Last. Richard M. Cubbon (University of Leeds)H-Index: 27
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OBJECTIVE Estimating survival can aid care planning, but the use of absolute survival projections can be challenging for patients and clinicians to contextualise. We aimed to define how heart failure and its major comorbidities contribute to loss of actuarially predicted life expectancy. METHODS We conducted an observational cohort study of 1794 adults with stable chronic heart failure and reduced left ventricular ejection fraction, recruited from cardiology outpatient departments of four UK hos...
2 CitationsSource
#1Mariana Blacher (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 1
#2André Zimerman (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 5
Last. Luis Eduardo Paim Rohde (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 48
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Objective New York Heart Association (NYHA) functional class plays a central role in heart failure (HF) assessment but might be unreliable in mild presentations. We compared objective measures of HF functional evaluation between patients classified as NYHA I and II in the Rede Brasileira de Estudos em Insuficiencia Cardiaca (ReBIC)-1 Trial. Methods The ReBIC-1 Trial included outpatients with stable HF with reduced ejection fraction. All patients had simultaneous protocol-defined assessment of NY...
1 CitationsSource
#1Catherine M Otto (UW: University of Washington)H-Index: 85
Acute coronary syndrome due to spontaneous coronary artery dissection (SCAD) typically is managed conservatively because coronary anatomy returns to normal in most patients at follow-up and because there is a high rate of technical failure and complications with percutaneous coronary intervention (PCI). However, a subgroup of these patients is at risk of extensive myocardial infarction and might benefit from PCI, despite the risk of complications. In this issue of Heart , Kotecha and colleagues1...
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#1Mary Yannakoulia (HUA: Harokopio University)H-Index: 51
#2Demosthenes B. Panagiotakos (HUA: Harokopio University)H-Index: 103
### Learning objectives Obesity, a chronic disease that develops from an interaction between genotype and environment, has already reached global epidemic proportions. From 1980 to 2015, the prevalence of overweight globally increased almost 50% (from 26.5% to 39.0%) and that of obesity around 80% (from 7% to 12.5%).1 The American and the European regions have the highest rates, but increasing prevalence has been reported across all regions, in both sexes and at all ages.1 Having a higher than a...
1 CitationsSource
#1Olivier Hanon (University of Paris)H-Index: 28
#2Jean-Sébastien Vidal (University of Paris)H-Index: 26
Last. Anne Sophie Boureau (Centre Hospitalier Universitaire de Nantes)H-Index: 1
view all 21 authors...
Objective Direct oral anticoagulants have been evaluated in the general population, but proper evidence for their safe use in the geriatric population is still missing. We compared the bleeding risk of a direct oral anticoagulant (rivaroxaban) and vitamin K antagonists (VKAs) among French geriatric patients with non-valvular atrial fibrillation (AF) aged ≥80 years. Methods We performed a sequential observational prospective cohort study, using data from 33 geriatric centres. The sample comprised...
4 CitationsSource
#1Jonathan Golledge (JCU: James Cook University)H-Index: 73
#2Tejas P. Singh (JCU: James Cook University)H-Index: 9
Objective There is currently no medical treatment proven to limit abdominal aortic aneurysm (AAA) progression. The aim of this systematic review and meta-analysis was to pool data from previous randomised controlled trials assessing the efficacy of blood pressure-lowering and antibiotic medications in limiting AAA growth and AAA-related events, that is, rupture or repair. Methods A systematic literature search was performed to identify randomised controlled trials that examined the efficacy of b...
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Surgery
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Heart failure
Heart disease
Myocardial infarction
Diabetes mellitus
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