Heart
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#1Catherine M Otto (UW: University of Washington)H-Index: 88
Patients with atrial fibrillation (AF) have a higher risk of dementia and mild cognitive impairment, in addition to a fivefold higher risk of stroke, compared with patients in normal sinus rhythm. Potential mechanisms of cognitive impairment or dementia related to AF include recurrent micro emboli versus cerebral hypoperfusion in association with increased oxidative stress, inflammation and disruption of the blood-brain barrier. Using linked electronic health records from the Clinical Practice R...
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#1Xinli Guo (SCU: Sichuan University)H-Index: 1
#2Rizhen Song (SCU: Sichuan University)H-Index: 2
Last. Yucheng Chen (SCU: Sichuan University)H-Index: 18
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A woman in her 70s was evaluated for fatigue and chest tightness for 4 months and oedema of both lower extremities for 1 month. She denied any medical history and family history of heart disorders. ECG showed normal QRS voltages with intraventricular block and left ventricular (LV) hypertrophy. Echocardiography showed severe aortic regurgitation (AR), asymmetric LV hypertrophy (maximum wall thickness of the septum 15 mm and 11 mm of the posterior wall) and normal LV size and ejection fraction of...
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#2N. Charlotte Onland-Moret (Utrecht University)H-Index: 51
Last. Leonard Hofstra (VUMC: Vanderbilt University Medical Center)
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Objectives null To investigate the impact of a CT-first strategy on all-cause and cardiovascular mortality in patients presenting with chest pain in outpatient cardiology clinics. null Methods null Patients with a first presentation of suspected angina pectoris were identified and their data linked to the registrations of Statistics Netherlands for information on mortality. The linked database consisted of 33 068 patients. CT-first patients were defined as patients with a CT calcium score and co...
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#1Michelle C. Williams (University of Edinburgh)H-Index: 30
#2David E. Newby (University of Edinburgh)H-Index: 108
Coronary artery disease remains the leading cause of death around the world, even during the COVID-19 pandemic, and it is therefore essential that we continue our quest to improve the prevention, diagnosis, management and outcome of coronary artery disease. Fifty years ago, in 1971, the first CT scan was performed on a machine invented by Sir Godfrey Hounsfield who, even in those early days, realised the potential of CT to assess the heart and coronary arteries.1 Technological advances mean that...
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#2Michael D. MiedemaH-Index: 2
Last. John A. Dodson (NYU: New York University)H-Index: 27
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The value of primary preventative therapies for cardiovascular disease (CVD) in older adults (age ≥75 years) is less certain than in younger patients. There is a lack of quality evidence in older adults due to underenrolment in pivotal trials. While aspirin is no longer recommended for routine use in primary prevention of CVD in older adults, statins may be efficacious. However, it is unclear which patient subgroups may benefit most, and guidelines differ between expert panels. Three relevant ge...
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#1Andrew MorrowH-Index: 6
#2Thomas J. FordH-Index: 16
Last. Colin BerryH-Index: 88
view all 31 authors...
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#1Froso SophocleousH-Index: 3
Last. Giovanni BiglinoH-Index: 20
view all 16 authors...
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#1Matthew WebberH-Index: 4
#2George JoyH-Index: 6
Last. Gabriella CapturH-Index: 26
view all 11 authors...
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#2Ambra MasiH-Index: 1
Last. Vanessa M. FerreiraH-Index: 22
view all 20 authors...
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#1Catherine M Otto (UW: University of Washington)H-Index: 88
Atrial fibrillation (AF) is a major cause of morbidity and mortality with an increasing prevalence in our ageing population. Yet, we have few effective approaches to identifying patients at risk of AF so that many patients are diagnosed only when they present with a stroke or heart failure. In this issue of Heart , Sanz-Garcia and colleagues1 present a simple ECG-based score that predicts subsequent AF with a predictive value area under the curve (AUC) of 0.776 (95% CI: 0.738 to 0.814). This com...
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