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Congenital heart diseases (CHD) are a heterogeneous group of conditions that afflict an increasing number of adults. On some occasions, the singularities of the anatomy and physiology are a real challenge for the treating cardiologist. Such is the case of patients with congenitally corrected transposition of the great arteries (ccTGA) and those with transposition of the great arteries (TGA) repaired with the atrial switch procedure, in which a morphologically right ventricle (RV) sustains the sy...
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#1Bart A. Mulder (UMCG: University Medical Center Groningen)H-Index: 10
#2Michiel Rienstra (UMCG: University Medical Center Groningen)H-Index: 53
Last. Yuri Blaauw (UMCG: University Medical Center Groningen)H-Index: 24
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Atrial fibrillation is increasingly encountered in patients with heart failure. Both diseases have seen tremendous rises in incidence in recent years. In general, the treatment of atrial fibrillation is focused on relieving patients from atrial fibrillation-related symptoms and risk reduction for thromboembolism and the occurrence or worsening of heart failure. Symptomatic relief may be accomplished by either (non-)pharmacological rate or rhythm control in combination with optimal therapy of und...
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#1Rishi J. Desai (Brigham and Women's Hospital)H-Index: 27
#2Elisabetta Patorno (Brigham and Women's Hospital)H-Index: 28
Last. Sebastian Schneeweiss (Brigham and Women's Hospital)H-Index: 110
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OBJECTIVE To evaluate the effectiveness of angiotensin receptor-neprilysin inhibitor (ARNI) versus renin-angiotensin system (RAS) blockade alone in older adults with heart failure with reduced ejection fraction (HFrEF). METHODS We conducted a cohort study using US Medicare fee-for-service claims data (2014-2017). Patients with HFrEF ≥65 years were identified in two cohorts: (1) initiators of ARNI or RAS blockade alone (ACE inhibitor, ACEI; or angiotensin receptor blocker, ARB) and (2) switchers ...
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#1Jan M. Griffin (Columbia University)H-Index: 4
#2Richard Cheng (University of Washington Medical Center)H-Index: 18
Over the last decade, treatment for heart failure with reduced ejection fraction (HFrEF) has advanced, with the incremental addition of novel evidence-based medical therapies. The landmark PARADIGM-HF (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) study showed that the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan was superior to enalapril in reducing risk of death and HF hospitalisations.1 This has paved ...
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OBJECTIVE Early prediction of atrial fibrillation (AF) development would improve patient outcomes. We propose a simple and cheap ECG based score to predict AF development. METHODS A cohort of 16 316 patients was analysed. ECG measures provided by the computer-assisted ECG software were used to identify patients. A first group included patients in sinus rhythm who showed an ECG with AF at any time later (n=505). A second group included patients with all their ECGs in sinus rhythm (n=15 811). By u...
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#1David S. Owens (UW: University of Washington)H-Index: 25
#2Traci M. Bartz (UW: University of Washington)H-Index: 38
Last. Jorge R. KizerH-Index: 60
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OBJECTIVES Current estimates of aortic stenosis (AS) frequency have mostly relied on cross-sectional echocardiographic or longitudinal administrative data, making understanding of AS burden incomplete. We performed case adjudications to evaluate the frequency of AS and assess differences by age, sex and race in an older cohort with long-term follow-up. METHODS We developed case-capture methods using study echocardiograms, procedure and diagnosis codes, heart failure events and deaths for targete...
1 CitationsSource
#1Xiaowen Wang (PKU: Peking University)H-Index: 10
#2Jia-Yi Dong (Osaka University)H-Index: 21
Last. Shoichiro TsuganeH-Index: 108
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OBJECTIVE To examine whether the relationship between smoking cessation and risk of cardiovascular disease (CVD) was modified by weight gain. METHODS A total of 69 910 participants (29 650 men and 46 260 women) aged 45-74 years were grouped into six groups by smoking status in the first and 5-year surveys: sustained smokers, recent quitters according to postcessation weight gain (no weight gain, 0.1-5.0 kg, >5.0 kg), long-term quitters and never smokers. Quitting smoking within and longer than 5...
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#1C. Chow (University of Melbourne)H-Index: 2
#2Om Narayan (Northern Hospital)
Last. Han Sung Lim (University of Melbourne)
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A female teenager presented with palpitations. The baseline rhythm on her ECG demonstrates sinus rhythm with normal PR interval of 120 ms, a mild degree of delta wave, RSR′ morphology in V1 with a precordial transition zone between V1 and V2. The frontal axis demonstrates normal QRS axis, in particular a positive lead III and aVF vectors, and negative aVR and aVL vectors, suggesting an overall inferior propagating QRS vector. Intermittently, however, she exhibits a different QRS morphology and a...
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#1William A E Parker (University of Sheffield)H-Index: 8
#2Robert F. Storey (University of Sheffield)H-Index: 90
### Learning objectives Globally, much morbidity and premature mortality arises from coronary artery disease (CAD). Coronary artery atherothrombosis is the dominant cause of acute coronary syndromes (ACS), including spontaneous myocardial infarction (MI) and unstable angina. Those with chronic coronary syndromes (CCS), including stable CAD or an ACS event >1 year ago, are at ongoing atherothrombotic risk.1 Modifiable or partially modifiable risk factors such as hypercholesterolaemia, diabetes me...
1 CitationsSource
#1Li Tan YangH-Index: 11
#1Li-Tan Yang (NTU: National Taiwan University)H-Index: 1
Last. Hector I. Michelena (Mayo Clinic)H-Index: 48
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Objective To comprehensively explore contemporary differences between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) patients with chronic haemodynamically significant aortic regurgitation (AR). Methods Consecutive patients with chronic ≥moderate-severe AR from a tertiary referral centre (2006–2017) were included. All-cause mortality, surgical indications and aortic valve surgery (AVS) were analysed. Results Of 798 patients (296 BAV-AR, age 46±14 years; 502 TAV-AR, age 67±14 years,...
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