The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage

Postpartum hemorrhage (PPH) is a major source of maternal morbidity.This study's objective was to determine whether changes in hemostasis markers during the course of PPH are predictive of its severity.We enrolled 128 women with PPH requiring uterotonic prostaglandin E2 (sulprostone) infusion. Two groups were defined (severe and non-severe PPH) according to the outcome during the first 24 hours. According to our criteria, 50 of the 128 women had...