Cytotoxicity of contact lens multipurpose solutions: Role of oxidative stress, mitochondrial activity and P2X7 cell death receptor activation

To investigate the cytotoxicity of multipurpose solutions used for contact lens disinfection.Four multipurpose solutions (Optifree containing quaternary ammonium as preservative, Renu, Solocare and Complete containing polyhexamethylene biguanide as preservative) were incubated on a conjunctival cell line to evaluate their capacity to induce necrosis (neutral red test), intracellular redox status alteration (Alamar Blue test), reactive oxygen...