Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses
Abstract
nsp1 protein of severe acute respiratory syndrome coronavirus (SARS-CoV), a group 2b CoV, suppresses host gene expression by promoting host mRNA degradation and translation inhibition. The present study analyzed the activities of nsp1 proteins from the group 2 bat CoV strains Rm1, 133, and HKU9-1, belonging to groups 2b, 2c, and 2d, respectively. The host mRNA degradation and translational suppression activities of nsp1 of SARS-CoV and Rm1 nsp1...
Paper Details
Title
Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses
Published Date
May 15, 2009
Journal
Volume
83
Issue
10
Pages
5282 - 5288
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