Composites of amorphous calcium phosphate and poly(hydroxybutyrate) and poly(hydroxybutyrate-co-hydroxyvalerate) for bone substitution: assessment of the biocompatibility

Composites of amorphous carbonated apatite and poly-(R)-3-hydroxybutyrate (PHB) and poly-(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate (PHBHV), respectively, were studied by pH monitoring upon immersion in water and by long-term osteoblast culture. For comparison, α-tricalcium phosphate (α-TCP), one glass ceramic (GB 9N), and one bioglass (Mg 5) were subjected to the same experiments. Excellent cell proliferation was found on the composite of...