Proximal tubule-dominant transfer of AT_1a receptors induces blood pressure responses to intracellular angiotensin II in AT_1a receptor-deficient mice

The role of intracellular ANG II in proximal tubules of the kidney remains poorly understood. We tested the hypothesis that proximal tubule-dominant transfer of AT 1a receptors in the cortex mediates intracellular ANG II-induced blood pressure responses in AT 1a receptor-deficient (Agtr1a-/-) mice. A GFP-tagged AT 1a receptor, AT 1a R/GFP, and an enhanced cyan fluorescent intracellular ANG II fusion protein, ECFP/ANG II, were expressed in...