American Journal of Physiology-regulatory Integrative and Comparative Physiology
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#1Ezidin G. Kaddumi (Al-Balqa` Applied University)H-Index: 1
#2Ali Al Khader (Al-Balqa` Applied University)H-Index: 1
Last. Sakher Tahaineh (Al-Balqa` Applied University)
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The cross talk between external genitalia and urinary bladder could be utilized as part of management to certain pathological conditions affecting urinary bladder. Since urinary bladder function is also affected by pathologies of other organs (e.g., colon and esophagus), the effect of genitalia stimuli on parameters of bladder function in normal or under different pathological conditions needs to be characterized. Cystometry recordings in male rats were used to examine the effect of low threshol...
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#1Rajshekhar A. Kore (University of Arkansas for Medical Sciences)H-Index: 9
#2Xianwei Wang (Xinxiang Medical University)H-Index: 28
Last. Jawahar L. Mehta (University of Arkansas for Medical Sciences)H-Index: 104
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Following an ischemic event, there is activation of fibroblasts leading to scar formation. It is critical to limit the pro-fibrotic remodeling and activate the reparative, remodeling phase to limit cardiac diastolic dysfunction. Mesenchymal stem cell (MSC) exosomes offer significant protection against ischemia-related systolic dysfunction. Here we studied if MSC exosomes would offer protection against pro-fibrotic events in mouse hearts subjected to acute ischemia (1 hr. left coronary artery occ...
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#1Richie P. Goulding (VU: VU University Amsterdam)
#2Simon Marwood (RMIT: RMIT University)H-Index: 11
Last. Shunsaku Koga (Kobe Design University)H-Index: 29
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INTRODUCTION/PURPOSE This study tested the hypothesis that the respiratory compensation point (RCP) and breakpoint in deoxygenated [heme] (deoxy[heme]BP, assessed via near-infrared spectroscopy (NIRS)) during ramp incremental exercise would occur at the same metabolic rate in the upright (U) and supine (S) body positions. METHODS Eleven healthy men completed ramp incremental exercise tests in U and S. Gas exchange was measured breath-by-breath and time-resolved-NIRS was used to measure deoxy[hem...
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#1Misa Horiike (Teikyo University)
#2Yoshiko Ogawa (Teikyo University)H-Index: 6
Last. Shigeo Kawada (Teikyo University)H-Index: 1
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Hyperoxic conditions are known to accelerate skeletal muscle regeneration after injuries. In the early phase of regeneration, macrophages invade the injured area and subsequently secrete various growth factors, which regulate myoblast proliferation and differentiation. Although hyperoxic conditions accelerate muscle regeneration, it is unknown whether this effect is indirectly mediated by macrophages. Here, using C2C12 cells, we show that not only hyperoxia but also hypoxia enhance myoblast prol...
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#1Jane I. Khudyakov (UOP: University of the Pacific (United States))H-Index: 12
#2Michael D. Treat (UNLV: University of Nevada, Las Vegas)H-Index: 2
Last. Frank van Breukelen (UNLV: University of Nevada, Las Vegas)H-Index: 14
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Many mammals use adaptive heterothermy (e.g. torpor, hibernation) to reduce metabolic demands of maintaining high body temperature (Tb). Torpor is typically characterized by coordinated declines in...
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#1Veena S. Rao (Yale University)H-Index: 11
#2Christopher Maulion (Yale University)H-Index: 3
Last. Christopher S. Wilcox (Georgetown University)H-Index: 71
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Congestion is the primary pathophysiologic lesion in most heart failure (HF) hospitalizations. Renal congestion increases renal tubular pressure, reducing glomerular filtration rate (GFR) and diuresis. Because each nephron is a fluid filled column, renal negative pressure therapy (rNPT) applied to the urinary collecting system should reduce tubular pressure, potentially improving kidney function. We evaluated the renal response to rNPT in congestive HF. Ten anesthetized ∼80 kg pigs underwent ins...
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#1Richard Leandro Spinieli (MU: University of Missouri)H-Index: 1
#2Ruwaida Ben Musa (MU: University of Missouri)
Last. Kevin J. Cummings (MU: University of Missouri)H-Index: 8
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Orexin neurons are active in wakefulness and mostly silent in sleep. In adult rats and humans, orexin facilitates the hypercapnic ventilatory response, but has little effect on resting ventilation. The influence of orexin on breathing in the early postnatal period, and across states of vigilance, have not been investigated. This is relevant as the orexin system may be impaired in Sudden Infant Death Syndrome (SIDS) cases. We addressed three hypotheses: 1) orexin provides a drive to breathe in in...
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#1Vi Pham (Western University College of Veterinary Medicine)
#2Joshua G. Pemberton (U of A: University of Alberta)H-Index: 9
Last. Suraj Unniappan (Western University College of Veterinary Medicine)H-Index: 30
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Stress in vertebrates is mediated by the hypothalamus-pituitary-adrenal [in mammals]/interrenal [ in fish] (HPA/I) axis, which produces the corticotropin releasing factor (CRF), adrenocorticotropic hormone (ACTH) and corticosteroids, respectively. Nesfatin-1, a novel anorexigenic peptide encoded in the precursor nucleobindin-2 (NUCB2), is increasingly acknowledged as a peptide that influences the stress axis in mammals. The primary aim of this study was to characterize the putative effects of ne...
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Erythrocyte enucleation is thought to have evolved in mammals to support their energetic cost of high metabolic activities. However, birds face similar selection pressure yet possess nucleated erythrocytes. Current hypotheses on the mammalian erythrocyte enucleation claim that the absence of cell organelles allows erythrocytes to 1) pack more hemoglobin into the cells to increase oxygen carrying capacity and 2) decrease erythrocyte size for increased surface area-to-volume ratio, and improved ab...
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#1Takuto Hamaoka (PSU: Pennsylvania State University)
#2Cheryl Blaha (PSU: Pennsylvania State University)H-Index: 15
Last. Jian Cui (PSU: Pennsylvania State University)H-Index: 19
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The effects of nitroglycerin (glyceryl trinitrate, GTN) on baroreflex sensitivity (BRS) are incompletely understood. Moreover, there are no reports evaluating the acute responses in both the sympat...
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