Original paper
Genetic variability of the μ-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women ☆
Abstract
Labor initiates one of the most intensely painful episodes in a woman's life. Opioids are used to provide analgesia with substantial interindividual variability in efficacy. mu-Opioid receptor (muOR, OPRM1) genetic variants may explain differences in response to opioid analgesia. We hypothesized that OPRM1 304A/G polymorphism influences the median effective dose (ED(50)) of intrathecal fentanyl via combined spinal-epidural for labor analgesia....
Paper Details
Title
Genetic variability of the μ-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women ☆
Published Date
Sep 30, 2008
Journal
Volume
139
Issue
1
Pages
5 - 14
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Notes
History