Pharmacokinetic analysis of tissue microcirculation using nested models: Multimodel inference and parameter identifiability

The purpose of this study is to evaluate the identifiability of physiological tissue parameters by pharmacokinetic modeling of concentration‐time curves derived under conditions that are realistic for dynamic‐contrast‐enhanced (DCE) imaging and to assess the information‐theoretic approach of multimodel inference using nested models. Tissue curves with a realistic noise level were simulated by means of an axially distributed multipath reference...