Structure–function relationship of estrogen receptor α and β: Impact on human health
Abstract
17Beta-estradiol (E2) controls many aspects of human physiology, including development, reproduction and homeostasis, through regulation of the transcriptional activity of its cognate receptors (ERs). The crystal structures of ERs with agonists and antagonists and the use of transgenic animals have revealed much about how hormone binding influences ER conformation(s) and how this conformation(s), in turn, influences the interaction of ERs with...
Paper Details
Title
Structure–function relationship of estrogen receptor α and β: Impact on human health
Published Date
Aug 1, 2006
Volume
27
Issue
4
Pages
299 - 402
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