Maria Marino
Roma Tre University
EndocrinologyReceptorEstrogen receptor alphaChemistryApoptosisNeuroglobinEstrogenCancer researchBiochemistryMAPK/ERK pathwayCell growthSignal transductionMedicineProtein kinase BEstrogen receptorTranscription factorBiologyCell biologyCancer cellEstrogen receptor beta
Publications 162
#1Marco FiocchettiH-Index: 12
#2Patrizio CraccoH-Index: 1
Last. Maria Marino (Roma Tre University)H-Index: 43
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Abstract Dysfunctional mitochondria have severe consequences on cell functions including Reactive Oxygen Specie (ROS) generation, alteration of mitochondrial signaling, Ca2+ buffering, and activation of apoptotic pathway. These dysfunctions are closely linked with degenerative diseases including neurodegeneration. The discovery of neuroglobin (NGB) as an endogenous neuroprotective protein, which effects seem to depend on its mitochondrial localization, could drive new therapeutic strategies agai...
#1Iole Venditti (Roma Tre University)H-Index: 9
#1Iole Venditti (Roma Tre University)H-Index: 29
Last. Chiara Battocchio (Roma Tre University)H-Index: 25
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1 CitationsSource
#1Marco FiocchettiH-Index: 12
Last. Maria Marino (Roma Tre University)H-Index: 43
view all 8 authors...
1 CitationsSource
#1Emiliano MontalesiH-Index: 4
#2Manuela CipollettiH-Index: 8
Last. Maria Marino (Roma Tre University)H-Index: 43
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Although soy consumption is associated with breast cancer prevention, the low bioavailability and the extensive metabolism of soy-active components limit their clinical application. Here, the impact of daidzein (D) and its metabolites on estrogen-dependent anti-apoptotic pathway has been evaluated in breast cancer cells. In estrogen receptor α-positive breast cancer cells treated with D and its metabolites, single or in mixture, ERα activation and Neuroglobin (NGB) levels, an anti-apoptotic estr...
5 CitationsSource
#1Virginia Solar Fernandez (Roma Tre University)H-Index: 2
#1Virginia FernándezH-Index: 30
Last. Marco Fiocchetti (Roma Tre University)H-Index: 12
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Aims. Nuclear factor (erythroid-derived 2)-like-2 factor (NRF-2) is a transcription factor well known to provide an advantage for cancer growth and survival regulating the cellular redox pathway. I...
3 CitationsSource
Reactive oxygen species (ROS) result from intracellular aerobic metabolism and/or extracellular stimuli. Although endogenous antioxidant systems exquisitely balance ROS production, an excess of ROS production, commonly found in diverse human degenerative pathologies including cancer, gives rise to the oxidative stress. Increased oxidative stress in cancer is related to the sustained proliferation and metabolism of cancer cells. However, cancer cells show an intrinsic higher antioxidant capacity ...
6 CitationsSource
: Here, we investigated the protein network regulating cholesterol metabolism in the liver and brain of adolescent and adult male and female rats prenatally exposed to valproate (VPA), a well validated experimental model of autism spectrum disorders (ASD). We were aimed at studying whether prenatal VPA exposure affected the proteins involved in cholesterol homeostasis in a sex-dependent manner. To this aim the protein network of cholesterol metabolism, in term of synthesis and plasma membrane tr...
7 CitationsSource
The potential “health benefits” of dietary polyphenols have been ascribed to their direct antioxidant activity and their impact on the regulation of cell and tissue redox balance. However, because of the relative poor bioavailability of many of these compounds, their effects could not be easily explained by the antioxidant action, which may occur only at high circulating and tissue concentrations. Therefore, many efforts have been put forward to clarify the molecular mechanisms underlining the b...
23 CitationsSource
#1Valentina Brandi (Roma Tre University)H-Index: 4
#2Valentina Di Lella (Roma Tre University)H-Index: 1
Last. Fabio Polticelli (Roma Tre University)H-Index: 33
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A polyglutamine expansion of the N-terminal region of huntingtin (Htt) causes Huntington’s disease, a severe neurodegenerative disorder. Htt huge multidomain structure, the presence of disordered regions, and the lack of sequence homologs of known structure, so far prevented structural studies of Htt, making the study of its structure-function relationships very difficult. In this work, the presence and location of five Htt ordered domains (named from Hunt1 to Hunt5) has been detected and the st...
4 CitationsSource
#1Marco FiocchettiH-Index: 12
#2Manuela CipollettiH-Index: 8
Last. Maria MarinoH-Index: 26
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: Neuroglobin (NGB) is a relatively recent discovered monomeric heme-protein, which behave in neurons as a sensor of injuring stimuli including oxidative stress, hypoxia, and neurotoxicity. In addition, the anti-apoptotic activity of overexpressed NGB has been reported both in neurons and in cancer cell lines. We recently demonstrated that, NGB functions as a compensatory protein of the steroid hormone 17β-estradiol (E2) protecting cancer cells against the apoptotic death induced by oxidative st...
9 CitationsSource
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