Original paper
Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
Abstract
Methamphetamine (METH), an addictive psycho-stimulant drug with euphoric effect is known to cause neurotoxicity due to oxidative stress, dopamine accumulation and glial cell activation. Here we hypothesized that METH-induced interference of glucose uptake and transport at the endothelium can disrupt the energy requirement of the blood-brain barrier (BBB) function and integrity. We undertake this study because there is no report of METH effects...
Paper Details
Title
Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
Published Date
Mar 22, 2011
Journal
Volume
6
Issue
1
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Notes
History