Polysaccharide from Ganoderma atrum Evokes Antitumor Activity via Toll-like Receptor 4-Mediated NF-κB and Mitogen-Activated Protein Kinase Signaling Pathways

Ganoderma atrum has been used as a traditional Chinese medicine for centuries. In this study, the antitumor activity of a novel G. atrum polysaccharide (PSG-1) was investigated in vitro and in vivo using S180 tumor-bearing mice. The results showed that PSG-1 significantly inhibited the proliferation of S180 via the activation of macrophages in a dose-dependent manner. PSG-1-primed macrophages exhibited a higher tumoricidal activity than...