A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets
Abstract
The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR) may be a valuable predictor of islet quality and long term nutrient responsiveness. To date, high-throughput and user-friendly assays for islet respiration are lacking. The aim of this study was to develop such an assay and to examine bioenergetic efficiency of rodent and human islets.The...
Paper Details
Title
A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets
Published Date
May 14, 2012
Journal
Volume
7
Issue
5
Pages
e33023 - e33023
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