Spred-2 deficiency exacerbates acetaminophen‐induced hepatotoxicity in mice

MAPKs are involved in acetaminophen (APAP)-hepatotoxicity, but the regulatory mechanism remains unknown. Here, we explored the role of Spred-2 that negatively regulates Ras/ERK pathway in APAP-hepatotoxicity. Spred-2 knockout (KO) mice demonstrated exacerbated liver injury, an event that was associated with increased numbers of CD4+ T, CD8+ T and NK cells in the liver compared to the control. Levels of CXCL9/CXCL10 that attract and activate...