Original paper
Spred-2 deficiency exacerbates acetaminophen‐induced hepatotoxicity in mice
Abstract
MAPKs are involved in acetaminophen (APAP)-hepatotoxicity, but the regulatory mechanism remains unknown. Here, we explored the role of Spred-2 that negatively regulates Ras/ERK pathway in APAP-hepatotoxicity. Spred-2 knockout (KO) mice demonstrated exacerbated liver injury, an event that was associated with increased numbers of CD4+ T, CD8+ T and NK cells in the liver compared to the control. Levels of CXCL9/CXCL10 that attract and activate...
Paper Details
Title
Spred-2 deficiency exacerbates acetaminophen‐induced hepatotoxicity in mice
Published Date
Sep 1, 2012
Journal
Volume
144
Issue
3
Pages
272 - 282
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Notes
History