Hiroshi Wakabayashi
Okayama University
IrradiationInternal medicineEndocrinologySurgeryPathologyRetrospective cohort studyChemistryPediatricsMedical recordImmunologyLupus erythematosusVasculitisInfliximabDiseaseLipid peroxidationMitochondrionRat liverCancer researchInduction periodBiochemistryMedicineBiologyGastroenterology
21Publications
5H-index
47Citations
Publications 21
Newest
#1Hayato Nomura (Okayama University)H-Index: 3
#2Osamu Yamasaki (Okayama University)H-Index: 21
Last. Shin Morizane (Okayama University)H-Index: 17
view all 6 authors...
Source
#1Eri Katsuyama (Okayama University)H-Index: 16
Last. Jun WadaH-Index: 63
view all 15 authors...
We herein present a case of a 38-year-old man who had bamboo spine and severe sacroiliitis and who was diagnosed with ankylosing spondylitis (AS). Infliximab (IFX) markedly improved the axial symptom but was discontinued due to the side effect of peripheral neuropathy. Switching from IFX to etanercept worsened the side effect. Rituximab (RTX) administration elicited a good response without side effects. RTX might be a suitable option for AS therapy when TNF inhibitors are difficult to use.
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#1Kenji YamazakiH-Index: 1
Last. Masayuki KishidaH-Index: 11
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We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of D...
1 CitationsSource
#1Eri Katsuyama (Okayama University)H-Index: 16
#2Ken Ei Sada (Okayama University)H-Index: 19
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 12 authors...
: Idiopathic intracranial hypertension (IIH) is a syndrome of increased intracranial pressure and presents as an intractable headache, vomiting, and ophthalmologic manifestations. We herein report the case of a young girl who presented with bilateral abducens nerve palsy due to IIH as the onset of systemic lupus erythematosus (SLE). The patient was successfully treated with corticosteroid therapy. Our case lacked the typical symptoms of IIH, such as headache or nausea; therefore, it is necessary...
3 CitationsSource
#1Haruki Watanabe (Okayama University)H-Index: 8
#2Ryutaro YamanakaH-Index: 9
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 14 authors...
ObjectiveWe have assessed the effectiveness of tacrolimus for minor flares in systemic lupus erythematosus (SLE) patients.MethodsThe medical records of 313 patients were retrospectively reviewed over a period of seven years, from 2006 to 2013. We enrolled patients with minor flare treated with add-on tacrolimus, without glucocorticoid (GC) intensification (tacrolimus group). Minor flare was defined as a ≥1-point increase in a total score between 3 and 11 in the SLE Disease Activity Index (SLEDAI...
9 CitationsSource
Objective: To survey the current status and problems of cooperation between clinics and hospitals in Okayama Prefecture, Japan for the treatment of rheumatoid arthritis (RA). Methods: We distributed a questionnaire to 300 of the 983 Okayama Prefecture clinics that had either an internal medicine or orthopedic surgery department, from December 2013 to February 2014. The questionnaire covered practice pattern for RA treatment in clinics, current status of the hospital and clinic cooperation, and a...
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#1Chieko Kudo (Okayama University)H-Index: 6
#2Hiroshi Wakabayashi (Okayama University)H-Index: 5
Last. Shogo Takashiba (Okayama University)H-Index: 37
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Key Clinical Message We report a case of Behcet's disease which was aggravated by psychological stress and oral infection. The control of oral infection under medical and dental collaboration is important for providing Behcet's disease patients with the optimal medical care and for facilitating the relief of the primary disease.
1 CitationsSource
Source
#1Yoshinori Matsumoto (Okayama University)H-Index: 12
#2Ken Ei Sada (Okayama University)H-Index: 19
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
The current therapeutic regimen recommended by the European League against Rheumatism (EULAR) for anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is continuation of initially administered doses of glucocorticoids (GCs) in combination with cyclophosphamide (CYC) for 1 month followed by gradual tapering. Considering the adverse effects of GCs, another tapering regimen of GCs with CYC, which was characterized by tapering GCs weekly, was reported by the British Society of Rheumatolo...
5 CitationsSource
#1Hiroshi Wakabayashi (Okayama University)H-Index: 5
#2Toshihiro Ito (Okayama University)H-Index: 25
Last. Akihiro Matsukawa (Okayama University)H-Index: 43
view all 15 authors...
MAPKs are involved in acetaminophen (APAP)-hepatotoxicity, but the regulatory mechanism remains unknown. Here, we explored the role of Spred-2 that negatively regulates Ras/ERK pathway in APAP-hepatotoxicity. Spred-2 knockout (KO) mice demonstrated exacerbated liver injury, an event that was associated with increased numbers of CD4(+) T, CD8(+) T and NK cells in the liver compared to the control. Levels of CXCL9/CXCL10 that attract and activate these cells were increased in Spred-2 KO-liver. Kup...
10 CitationsSource