Original paper
The effectiveness of ranitidine in reducing gastric acid-secretion decreases with continued therapy.
Volume: 22, Issue: 6, Pages: 663 - 668
Published: Dec 1, 1986
Abstract
To examine whether changes in inhibition of gastric acid secretion occur during chronic ranitidine therapy, duodenal ulcer patients in remission were studied before and after 9 months of maintenance ranitidine therapy (150 mg nocte). At each time, the effect of a bolus i.v. dose of ranitidine (50 mg) on pentagastrin-stimulated maximal acid output was measured. Oral and intravenous pharmacokinetic studies were also performed to examine whether...
Paper Details
Title
The effectiveness of ranitidine in reducing gastric acid-secretion decreases with continued therapy.
Published Date
Dec 1, 1986
Volume
22
Issue
6
Pages
663 - 668
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Notes
History