Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism
Abstract
Blood vessels serve as key regulators of organogenesis by providing oxygen, nutrients and molecular signals. During limb development, programmed cell death (PCD) contributes to separation of the digits. Interestingly, prior to the onset of PCD, the autopod vasculature undergoes extensive patterning that results in high interdigital vascularity. Here, we show that in mice, the limb vasculature positively regulates interdigital PCD. In vivo,...
Paper Details
Title
Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism
Published Date
Jan 1, 2015
Journal
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History