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#1Tetsuya Bando (Okayama University)H-Index: 16
#2Misa Okumura (Okayama University)
Last. Kiyokazu Agata (Kyoto University)H-Index: 73
view all 12 authors...
Hemimetabolous insects, such as the two-spotted cricket Gryllus bimaculatus, can recover lost tissues in contrast to the limited regenerative abilities in human tissues. Following cricket leg amputation, the wound surface is covered by the wound epidermis, and plasmatocytes, which are insect macrophages, accumulate in the wound region. Here, we studied the function of Toll-related molecules identified by comparative RNA-seq during leg regeneration. Among 11 Toll genes in the Gryllus genome, expr...
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#1Mandy Busse (OvGU: Otto-von-Guericke University Magdeburg)H-Index: 12
#2Stefanie Langwisch (OvGU: Otto-von-Guericke University Magdeburg)H-Index: 8
Last. Ana C. Zenclussen (Leipzig University)H-Index: 1
view all 5 authors...
B cell participation in early embryo/fetal development and the underlying molecular pathways have not been explored. To understand whether maternal B cell absence or impaired signaling interferes with placental and fetal growth, we paired CD19-deficient (CD19-/-) mice, females with B cell-specific MyD88 (BMyD88-/-) or IL10 (BIL10-/-) deficiency as well as wild-type and MyD88-/- controls on C57Bl/6 background with BALB/c males. Pregnancies were followed by ultrasound and Doppler measurements. Imp...
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#1Aryan Kaveh (University of Edinburgh)H-Index: 2
#2Finnius A. Bruton (University of Edinburgh)H-Index: 3
Last. Martin A. Denvir (University of Edinburgh)H-Index: 28
view all 8 authors...
Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse outcomes following myocardial infarction (MI). An attractive therapeutic strategy to treat MI is to reduce or remove infiltrating neutrophils to promote downstream reparative mechanisms. CDK9 inhibitor compounds enhance the resolution of neutrophilic inflammation; however, their effects on cardiac repair/regeneration are unknown. We have devised a cardiac injury model to investigate inflammatory and...
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#1René Reitermaier (Medical University of Vienna)H-Index: 1
#2T. Ayub (Medical University of Vienna)H-Index: 2
Last. Wolfgang Eppel (Medical University of Vienna)H-Index: 18
view all 13 authors...
The adult human skin contains a vast number of T cells that are essential for skin homeostasis and pathogen defense. T cells are first observed in the skin at the early stages of gestation; however, our understanding of their contribution to early immunity has been limited by their low abundance and lack of comprehensive methodologies for their assessment. Here, we describe a new workflow for isolating and expanding significant amounts of T cells from fetal human skin. Using multiparametric flow...
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#1Nandor Nagy (Semmelweis University)H-Index: 25
#2Tamas Kovacs (Semmelweis University)H-Index: 1
Last. Allan M. Goldstein (Harvard University)H-Index: 36
view all 9 authors...
The enteric nervous system (ENS), which is derived from enteric neural crest cells (ENCCs), represents the neuronal innervation of the intestine. Compromised ENCC migration can lead to Hirschsprung Disease, which is characterized by an aganglionic distal bowel. During the craniocaudal migration of ENCCs along the gut, we find that their proliferation is greatest as the ENCC wavefront passes through the ceca, a paired structure at the midgut-hindgut junction in avian intestine. Removal of the cec...
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#1Robert G. Lloyd (University of Nottingham)H-Index: 72
#2Ramiro Alberio (University of Nottingham)H-Index: 29
Last. Brian I. Crother (SELU: Southeastern Louisiana University)H-Index: 22
view all 3 authors...
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#1Olivia Spead (USC: University of South Carolina)H-Index: 2
#2Cory J. Weaver (USC: University of South Carolina)H-Index: 4
Last. Fabienne E. Poulain (USC: University of South Carolina)H-Index: 11
view all 4 authors...
Organization of neuronal connections into topographic maps is essential for processing information. Yet, our understanding of topographic mapping has remained limited by our inability to observe maps forming and refining directly in vivo. Here, we used Cre-mediated recombination of a new colorswitch reporter in zebrafish to generate the first transgenic model allowing the dynamic analysis of retinotectal mapping in vivo. We found that the antero-posterior retinotopic map forms early but remains ...
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#1Jason A. Morrison (Stowers Institute for Medical Research)H-Index: 11
#2Rebecca McLennan (Stowers Institute for Medical Research)H-Index: 18
Last. Paul M. Kulesa (Stowers Institute for Medical Research)H-Index: 29
view all 7 authors...
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#1Robert N. Kelsh (University of Bath)H-Index: 59
#2Karen Camargo Sosa (University of Bath)H-Index: 4
Last. Andrea Rocco (University of Surrey)H-Index: 19
view all 6 authors...
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