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#1Corey Bunce (Duke University)H-Index: 3
#2Jennifer McKey (Duke University)H-Index: 4
Last. Blanche Capel (Duke University)H-Index: 67
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During development of the mouse urogenital complex, the gonads undergo changes in three-dimensional structure, body position, and spatial relationship with the mesonephric ducts, kidneys, and adrenals. The complexity of genital ridge development obscures potential connections between morphogenesis and gonadal sex determination. To characterize the morphogenic processes implicated in regulating gonad shape and fate, we used whole embryo tissue clearing and light sheet microscopy to assemble a tim...
1 CitationsSource
#1Chloé Roffay (Curie Institute)
#2Chii J. ChanH-Index: 11
Last. François Graner (University of Paris)
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Recognizing the crucial role of mechanical regulation and forces in tissue development and homeostasis has stirred a demand for in situ measurement of forces and stresses. Among emerging techniques, the use of cell geometry to infer cell junction tensions, cell pressures and tissue stress has gained popularity owing to the development of computational analyses. This approach is non-destructive and fast, and statistically validated based on comparisons with other techniques. However, its qualitat...
#1Neil R. Horner (Medical Research Council)H-Index: 9
#2Shanmugasundaram Venkataraman (Edin.: University of Edinburgh)H-Index: 10
Last. Ann-Marie Mallon (Medical Research Council)H-Index: 30
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Advanced 3D imaging modalities, such as micro computed tomography (micro-CT), have been incorporated into the high-throughput embryo pipeline of the International Mouse Phenotyping Consortium (IMPC). This project generates large volumes of raw data that cannot be immediately exploited without significant resources of manpower and expertise. Thus, rapid automated annotation is critical to ensure that 3D imaging data can be integrated with other multi-dimensional phenotyping data. We present an au...
#1Nicolas Toussaint ('KCL': King's College London)H-Index: 13
#2Yushi Redhead ('KCL': King's College London)H-Index: 1
Last. Jeremy B. Green ('KCL': King's College London)H-Index: 30
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Characterising phenotypes often requires quantification of anatomical shape. Quantitative shape comparison (morphometrics) traditionally uses manually located landmarks and is limited by landmark number and operator accuracy. Here, we apply a landmark-free method to characterise the craniofacial skeletal phenotype of the Dp1Tyb mouse model of Down syndrome and a population of the Diversity Outbred (DO) mouse model, comparing it with a landmark-based approach. We identified cranial dysmorphologie...
1 CitationsSource
#1Daisy J. Vinter (University of Manchester)
#2Caroline Hoppe (University of Manchester)H-Index: 3
Last. Hilary L. Ashe (University of Manchester)H-Index: 20
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The Hunchback (Hb) transcription factor is critical for anterior-posterior patterning of the Drosophila embryo. Despite the maternal hb mRNA acting as a paradigm for translational regulation, due to its repression in the posterior of the embryo, little is known about the translatability of zygotically transcribed hb mRNAs. Here we adapt the SunTag system, developed for imaging translation at single mRNA resolution in tissue culture cells, to the Drosophila embryo to study the translation dynamic...
#1Martina Nagel (U of T: University of Toronto)H-Index: 7
#2Debanjan Barua (U of T: University of Toronto)H-Index: 3
Last. Rudolf Winklbauer (U of T: University of Toronto)H-Index: 31
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During Xenopus gastrulation, leading edge mesendoderm (LEM) advances animally as wedge-shaped cell mass over the vegetally moving blastocoel roof (BCR). We show that close contact across the BCR-LEM interface correlates with attenuated net advance of the LEM, which is therefore pulled forward by tip cells while the remaining LEM frequently separates from the BCR. Nevertheless, lamellipodia persist on the detached LEM surface. They attach to adjacent LEM cells and depend on PDGF-A, cell surface f...
#1Ching-In Lau (ICH: UCL Institute of Child Health)H-Index: 9
#2Jasmine Rowell (ICH: UCL Institute of Child Health)H-Index: 1
Last. Tessa Crompton (ICH: UCL Institute of Child Health)H-Index: 31
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During positive selection at the transition from CD4+CD8+ double-positive (DP) to single positive (SP) thymocyte, TCR signalling results in appropriate MHC-restriction and signals for survival and progression. We show that the pioneer transcription factors Foxa1 and Foxa2 are required to regulate RNA splicing during positive selection. Foxa1 and Foxa2 had overlapping/compensatory roles. Conditional deletion of both Foxa1 and Foxa2 from DP thymocytes reduced positive selection and development of ...
#1Juli Liu (IU: Indiana University)H-Index: 4
#2Sheng Liu (IU: Indiana University)H-Index: 20
Last. Lei Yang (IU: Indiana University)H-Index: 4
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Polycomb Repressive Complex 2 (PRC2) deposits H3K27me3 on chromatin to silence transcription. PRC2 broadly interacts with RNAs. Currently, the role of RNA- PRC2 interaction in human cardiogenesis remains elusive. Here, we found human-specific Heart Brake LncRNA 1 (HBL1) interacted with two PRC2 subunits, JARID2 and EED, in human pluripotent stem cells (hPSCs). Loss-of-JARID2, EED or HBL1 significantly enhanced cardiac differentiation from hPSCs. HBL1 depletion disrupted genome-wide PRC2 occupanc...
#1Julian Ohiro Kimura (Harvard University)
#2Lorenzo Ricci (Harvard University)H-Index: 4
Last. Mansi Srivastava (Harvard University)H-Index: 14
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Acoels are marine worms that belong to the phylum Xenacoelomorpha, a deep-diverging bilaterian lineage. This makes acoels an attractive system for studying the evolution of major bilaterian traits. Thus far, acoel development has not been described in detail at the morphological and transcriptomic levels in a species in which functional genetic studies are possible. We present a set of developmental landmarks for embryogenesis in the highly regenerative acoel Hofstenia miamia. We generated a dev...
#2Vincent PoupartH-Index: 1
Last. Jean-Claude Labbé (UdeM: Université de Montréal)H-Index: 13
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The C. elegans germline is organized as a syncytium in which each germ cell possesses an intercellular bridge that is maintained by a stable actomyosin ring and that connects it to a common pool of cytoplasm, termed the rachis. How germ cells undergo cytokinesis while maintaining this syncytial architecture is not completely understood. Here we use live imaging to characterize primordial germ cell (PGC) division in C. elegans first-stage larvae. We show that each PGC possesses a stable intercell...
Top fields of study
Cell biology