Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)
Abstract
Pertussis toxin (PTX) is a typical A-B toxin. The A-protomer (S1 subunit) exhibits ADP-ribosyltransferase activity. The B-oligomer consists of four subunits (S2 to S5) and binds extracellular molecules that allow the toxin to enter the cells. The A-protomer ADP-ribosylates the α subunits of heterotrimeric Gi/o proteins, resulting in the receptors being uncoupled from the Gi/o proteins. The B-oligomer binds proteins expressed on the cell surface,...
Paper Details
Title
Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)
Published Date
Jul 15, 2011
Journal
Volume
3
Issue
7
Pages
884 - 899
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