138. Targeted Adenoviral Vectors Expressing Soluble TGFβRIIFc for Breast Cancer Metastasis

Bone metastases are present in most patients with advanced disease and can cause severe morbidity. Transforming growth factor-beta (TGF-beta) plays an important role in the tumor cell-bone interactions resulting in bone destruction. Previously, we have made an oncolytic adenovirus rAd-sTRIIFc, which expresses soluble TGFβRIIFc for targeting breast cancer bone metastasis by destroying tumor cells while simultaneously blocking the TGF-beta...