Original paper
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
Abstract
Recent studies have indicated that the regulation of innate immunity and energy metabolism are connected together through an antagonistic crosstalk between NF-κB and SIRT1 signaling pathways. NF-κB signaling has a major role in innate immunity defense while SIRT1 regulates the oxidative respiration and cellular survival. However, NF-κB signaling can stimulate glycolytic energy flux during acute inflammation, whereas SIRT1 activation inhibits...
Paper Details
Title
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
Published Date
Oct 1, 2013
Journal
Volume
25
Issue
10
Pages
1939 - 1948
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Notes
History