Validation of a Small Animal Model for Soft Tissue Filler Characterization

Background Rigorous preclinical testing of soft tissue fillers has been lacking. No animal model has emerged as an accepted standard to evaluate tissue filler longevity. Objective To validate a small animal model to compare soft tissue filler degradation and tissue reaction. Methods Preliminary experiments compared caliper with magnetic resonance imaging volumetric analysis. Next, four hyaluronic acid (HA) fillers were injected into the dermis...