HEPATOPROTECTIVE EFFECTS OF 18β-GLYCYRRHETINIC ACID ON CARBON TETRACHLORIDE-INDUCED LIVER INJURY: INHIBITION OF CYTOCHROME P450 2E1 EXPRESSION

The protective effects of 18beta-glycyrrhetinic acid (GA), the aglycone of glycyrrhizin (GL) derived from licorice, on carbon tetrachloride-induced hepatotoxicity and the possible mechanisms involved in this protection were investigated in mice. Pretreatment with GA prior to the administration of carbon tetrachloride significantly prevented an increase in serum alanine, aspartate aminotransferase activity and hepatic lipid peroxidation in a...