Expression of tumour necrosis factor-α and its receptors in Hodgkin lymphoma

In Hodgkin lymphoma (HL) patients, serum tumour necrosis factor-α (TNF-α, also termed TNF), TNF-α receptor 1 (TNFR1, also termed TNFRSF1B), and TNFR2 (also termed TNFRSF1B) levels are significantly higher than those in control subjects (Gruss et al, 1993; Salles et al, 1996; Metkar et al, 2000). Therefore, we evaluated the expression frequencies of TNF-α and TNFRs in HL and identified the cells from which Hodgkin and Reed/Sternberg (HRS) and...