Fabrication of sub-micron protein-chitosan electrostatic complexes for encapsulation and pH-Modulated delivery of model hydrophilic active compounds

Electrostatic sub-micron complexes of a protein (sodium caseinate (NaCAS) or bovine serum albumin (BSA)) and a polysaccharide (chitosan) were fabricated by associative phase separation and investigated for use in encapsulation and pH-triggered delivery applications. Various factors have been studied with respect to the extent of complexing and the size and morphology of the complexes produced, including protein type and the biopolymer mixing...