Distinguishing severe asthma phenotypes☆Role of age at onset and eosinophilic inflammation

Asthma is a heterogeneous process, yet little is understood regarding phenotypes.To determine whether phenotypic differences exist between early-onset, severe asthma as compared with late-onset disease and whether the presence or absence of eosinophilia influences the phenotypes.Cross-sectional analysis of integrated clinical, physiologic, and pathologic data collected from 80 subjects with severe asthma. Subjects were divided into those with...