Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout

Objective To profile monosodium urate monohydrate (MSU) crystal–recruited monocyte inflammatory function during the course of in vivo differentiation, in a murine model of peritoneal MSU crystal–induced inflammation. Methods C57BL/6J mice were injected intraperitoneally with MSU crystals, and the peritoneal cells were harvested at different time points. The MSU crystal–recruited monocyte/macrophage population was analyzed for the expression of...