Substance P enhances mesenchymal stem cells-mediated immune modulation
Abstract
Since clinical application of MSCs requires long-term ex vivo culture inducing senescence in MSCs and reducing the therapeutic activity of transplanted MSCs, numerous efforts have been attempted to sustain the active state of MSCs. Substance P (SP) is a neuropeptide that functions to activate the cellular physiological responses of MSCs, including proliferation, migration, and secretion of specific cytokines. In this study, we explored the...
Paper Details
Title
Substance P enhances mesenchymal stem cells-mediated immune modulation
Published Date
Feb 1, 2015
Journal
Volume
71
Issue
2
Pages
145 - 153
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History