Youngsook Son
Kyung Hee University
EndocrinologyPathologyMolecular biologyAdipose tissueChemistryMesenchymal stem cellImmunologySubstance PInflammationCytokineBone marrowWound healingStem cellTransplantationMathematicsCancer researchMedicineBiologyCell biologyPharmacology
138Publications
23H-index
1,698Citations
Publications 138
Newest
#1Jiyuan Piao (Kyung Hee University)H-Index: 4
#2Jeong Seop Park (Kyung Hee University)H-Index: 2
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 5 authors...
Aortic injuries, including aortic aneurysms and dissections, are fatal vascular diseases with distinct histopathological features in the aortic tissue such as inflammation-induced endothelial dysfunction, infiltration of immune cells, and breakdown of the extracellular matrix. Few treatments are available for treating aortic aneurysms and dissections; thus, basic and clinical studies worldwide have been attempted to inhibit disease progression. Substance P (SP) exerts anti-inflammatory effects a...
Source
#1Hyunji ChoH-Index: 2
#2Jisoo LeeH-Index: 2
Last. EunAh LeeH-Index: 11
view all 7 authors...
Near the bone remodeling compartments (BRC), extracellular calcium concentration (Ca2+o) is locally elevated and bone marrow stromal cells (BMSCs) close to the BRC can be exposed to high calcium concentration. The calcium-sensing receptor (CaSR) is known to play a key role in maintaining extracellular calcium homeostasis by sensing fluctuations in the levels of extracellular calcium (Ca2+o). When human BMSCs (hBMSCs) were exposed to various calcium concentrations (1.8, 3, 5, 10, 30 mM), moderate...
Source
#1Donghyun Nam (Kyung Hee University)H-Index: 3
#2Aran Park (Kyung Hee University)H-Index: 1
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 7 authors...
Endogenous bone marrow-derived mesenchymal stem cells are mobilized to peripheral blood and injured tissues in response to changes in the expression of various growth factors and cytokines in the injured tissues, including substance P (SP), transforming growth factor-beta (TGF-β), and stromal cell-derived factor-1 (SDF-1). SP, TGF-β, and SDF-1 are all known to induce the migration of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, it is not yet clear how these stimuli influence or...
Source
#1Jiyuan Piao (Kyung Hee University)H-Index: 4
#2Jeong Seop Park (Kyung Hee University)H-Index: 2
Last. Hyun Sook Hong (Kyung Hee University)H-Index: 11
view all 5 authors...
Osteoporosis is an age-related disease caused by imbalanced bone remodeling resulting from excessive bone resorption. Osteoporosis is tightly linked with induction of chronic inflammation, which activates osteoclasts and impairs osteoprogenitor in bone marrow. T helper 17 (Th17) cells have been recently recognized as one of major inducers in the pathophysiology of bone loss by secreting IL-17. Thus, modulation of Th17 development is anticipated to affect the progression of osteoporosis. Substanc...
Source
#1Sang-Min Baek (Kyung Hee University)H-Index: 1
#2Ki-Young Kim (Kyung Hee University)H-Index: 17
Last. Seung-Young Yu (Kyung Hee University)H-Index: 12
view all 6 authors...
Type 2 diabetic mellitus (T2DM) is characterized by systemic inflammation and insulin resistance due to obesity, and this leads to critical complications, including retinopathy and nephropathy. This study explored the therapeutic effect of substance-p (SP), a neuropeptide, on T2DM progression and its complications. To examine whether SP affects glucose metabolism, lipid metabolism, systemic inflammation, and retinopathy, Otsuka Long-Evans Tokushima Fatty rats (OLETF, 27 weeks old) with chronic i...
Source
#1Hyun Sook Hong (Kyung Hee University)H-Index: 11
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 4 authors...
Bone marrow mesenchymal stem cell (MSC) therapy acts through multiple differentiations in damaged tissue or via secretion of paracrine factors, as demonstrated in various inflammatory and ischaemic diseases. However, long-term ex vivo culture to obtain a sufficient number of cells in MSC transplantation leads to cellular senescence, deficiency of the paracrine potential, and loss of survival rate post-transplantation. In this study, we evaluated whether supplementation of MSCs with substance P (...
Source
#1Dong-Jin Kim (Kyung Hee University)H-Index: 11
#2Ju-Young Moon (Kyung Hee University)H-Index: 20
Last. Sang-Ho Lee (Kyung Hee University)H-Index: 54
view all 12 authors...
Substance P (SP), an injury-inducible messenger that mobilizes bone marrow stem cells and modulates the immune response, has been suggested as a novel target for therapeutic agents. We evaluated the role of SP as an immune cell modulator during the progression of renal ischemic/reperfusion injury (IRI). Unilateral IRI induced the transient expression of endogenous SP and the infiltration of CCR7+ M1 macrophages in injured kidneys. However, SP altered the intrarenal macrophage polarization from C...
2 CitationsSource
#1Wheemoon Cho (Kyung Hee University)H-Index: 3
#2Min Sup KimH-Index: 11
Last. Chun-Ho KimH-Index: 12
view all 9 authors...
Abstract Lysyl oxidase (LOX) is a cell-secreted amine oxidase that crosslinks collagen and elastin in extracellular microenvironment. LOX-traceable nanoparticles (LOXab-NPs) consisting of LOX antibodies (LOXab) and paclitaxel, can accumulate at high concentrations at radiation-treated target sites, as a tumor-targeting drug carrier for chemotherapy. Tumor-targeting and anticancer effect of PLGA based LOXab-NPs in vitro and in vivo were evaluated at radiation-targeted site. In the in vivo A549 lu...
2 CitationsSource
#1Seungwoo Nam (Kyung Hee University)H-Index: 5
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 5 authors...
Use of bone marrow aspirate (BMA) is a clinically advantageous cell therapeutic that bypasses the need for elaborate ex vivo cell culturing. However, a low level of bone marrowmesenchymal stem cells (BMMSCs) in the BMA and weak survival rate of these cells posttransplantation entails an insufficient efficacy in vivo. Moreover, stem cell activity in BMA is impaired by age or background diseases. Thus, in order to enrich the BMMSC pool and improve cell survival, novel cell preconditioning technolo...
Source
#1Hyun Ji Park (Yonsei University)H-Index: 16
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Seung Woo Cho (Yonsei University)H-Index: 51
view all 8 authors...
Abstract Substance P (SP) is a therapeutic peptide that has been widely used to induce angiogenesis and tissue regeneration. However, its therapeutic efficacy is often limited due to rapid degradation in vivo and a short half-life (˜1 min) after systemic administration. In the present study, we chemically modified SP with polyethylene glycol (PEG) to generate long-lasting formulations with increased stability and extended retention time in vivo and evaluated their ability to enhance therapeutic ...
3 CitationsSource