“Super p53” Mice Display Retinal Astroglial Changes
Abstract
Tumour-suppressor genes, such as the p53 gene, produce proteins that inhibit cell division under adverse conditions, as in the case of DNA damage, radiation, hypoxia, or oxidative stress (OS). The p53 gene can arrest proliferation and trigger death by apoptosis subsequent to several factors. In astrocytes, p53 promotes cell-cycle arrest and is involved in oxidative stress-mediated astrocyte cell death. Increasingly, astrocytic p53 is proving...
Paper Details
Title
“Super p53” Mice Display Retinal Astroglial Changes
Published Date
Jun 7, 2013
Journal
Volume
8
Issue
6
Pages
e65446 - e65446
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