Toxic effects of sorafenib when given early after allogeneic hematopoietic stem cell transplantation

To the editor: We read with interest the article by Metzelder et al showing sorafenib had antileukemic activity and could be given safely to patients with FLT-3 mutated AML relapsing after allogeneic stem cell transplantation (ASCT).1 Because sorafenib delays progression of renal cell carcinoma, we administered this drug to patients who had progression of metastatic kidney cancer after an ASCT. Besides the classic sorafenib hand-foot...