Protein Kinase Cδ Plays a Non-redundant Role in Insulin Secretion in Pancreatic β Cells
Abstract
Protein kinase C (PKC) is considered to modulate glucose-stimulated insulin secretion. Pancreatic β cells express multiple isoforms of PKCs; however, the role of each isoform in glucose-stimulated insulin secretion remains controversial. In this study we investigated the role of PKCδ, a major isoform expressed in pancreatic β cells on β cell function. Here, we showed that PKCδ null mice manifested glucose intolerance with impaired insulin...
Paper Details
Title
Protein Kinase Cδ Plays a Non-redundant Role in Insulin Secretion in Pancreatic β Cells
Published Date
Jan 1, 2007
Volume
282
Issue
4
Pages
2707 - 2716
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