Primary Melanoma of the Right Colon Presenting With Gastrointestinal Bleeding

Published on Aug 5, 2013in The Open Gastroenterology Journal
· DOI :10.2174/1874259901307010001
Busuttil Gerald1
Estimated H-index: 1
,
Blazic Ivan1
Estimated H-index: 1
+ 2 AuthorsBabic Darko1
Estimated H-index: 1
Sources
Abstract
A 73 year old female presented with painless fresh rectal bleeding and anaemia. At colonoscopy, a large mass arising from the right colon was visualised and biopsied. Histological evaluation established a diagnosis of melanoma. Thorough clinical examination confirmed the presence of primary localised melanoma which was amenable to resection. At laparotomy, right hemicolectomy and lymphadenectomy were performed. Two years after her surgery, our patient is well without any evidence of disease recurrence. Primary melanoma of the colon is a very rare clinical entity and limited data are available regarding its pathogenesis, treatment and outcome. Primary surgical resection in localised disease appears to be the mainstay of treatment, although the role of adjuvant therapy is still to be established.
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Targeted therapies for malignant melanoma have improved patients' prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune check...
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