Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model

Volume: 268, Issue: 2, Pages: 178 - 187
Published: Apr 1, 2013
Abstract
The endoplasmic reticulum (ER) stress response is a cell survival pathway upregulated when cells are under severe stress. Severely damaged mouse ear skin exposed to the vesicant, sulfur mustard (bis-2-chloroethyl sulfide, SM), resulted in increased expression of ER chaperone proteins that accompany misfolded and incorrectly made proteins targeted for degradation. Time course studies with SM using the mouse ear vesicant model (MEVM) showed...
Paper Details
Title
Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model
Published Date
Apr 1, 2013
Volume
268
Issue
2
Pages
178 - 187
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