Gel Based Iontophoretic Delivery System for Enhanced Transdermal Permeation of Alendronate Sodium

The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Alendronate Sodium (AS) by iontophoresis in combination with penetration enhacers. For better bioavailability, better patient compliance, and prevention of gastro-intestinal irritation of AS, an iontophoretic drug delivery system of AS gel was formulated using Carbopol-940. Optimization of gel indicated the suitability of the Carbopol...