M. H. G. Dehghan
Dr. Babasaheb Ambedkar Marathwada University
Pharmaceutical formulationMatrix (chemical analysis)Analytical chemistryAccelerated agingBiomedical engineeringNuclear chemistryDissolution testingSolubilityFactorial experimentBioavailabilityIontophoresisChemistryParticle sizeMaterials scienceBuccal administrationFirst pass effectQuality by DesignTransdermalIn vivoEthyl cellulosePhosphoric acidSodium benzoateFolding enduranceHydrotropeSwellingNasal cavitySodium salicylateSilica gelDrug deliveryFlunisolideDrugCorrelation coefficientCritical quality attributesNasal sprayDelivery systemMethod developmentHplc methodMathematicsChromatographyPotassiumRelative standard deviationPolymerStarchSodiumPlasticizerMucous membrane of noseMedicineLinearityDosage formNasal administrationDissolutionPhosphate buffered salineAbsorbancePharmacology
30Publications
9H-index
221Citations
Publications 35
Newest
#9Amol A. Tagalpallewar (MIT: Massachusetts Institute of Technology)H-Index: 6
#2M. H. G. DehghanH-Index: 9
Background and Aims: Invasive pulmonary aspergillosis (IPA) is an imperative concern in the present era due to its high occurrence and mortality rate in severely immunocompromised patients. The present study was designed to develop, optimize and characterize encapsulated nystatin (NYS) cubosome nanoparticles as an inhalable system, a viable alternative for effective management of IPA. Methods: A dry lipidic film comprising glycerol monooleate (GMO), Span 83, Poloxamer (P-407) and dispersed NYS w...
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#1Nazimuddin ChishtiH-Index: 1
#2M. H. G. DehghanH-Index: 9
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#3M. H. G. DehghanH-Index: 9
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#1Nazimuddin ChishtiH-Index: 1
#2Satveer JagwaniH-Index: 7
Last. M. H. G. DehghanH-Index: 9
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Background and Oobjectives: Lung cancer, a pressing issue in present-day society due to its high prevalence and mortality rate, can be managed effectively by long-term delivery of anticancer agents encapsulated in nanoparticles in the form of inhalable dry powder. This approach is expected to be of strategic importance in the management of lung cancer and is a developing area in current research. In the present investigation, we report on the formulation and characterization of docetaxel inhalab...
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AbstractThe objective of the present study was to design and develop drug-device combination product in particular flunisolide nasal spray (FNS) using quality by design (QbD) approach. Quality target product profile (QTPP) of FNS was defined and critical quality attributes (CQAs), i.e. viscosity (cp) (Y1) and D50 droplet size distribution (DSD) (μm) (Y2) were identified. Potential risk factors were identified using a fish bone diagram and failure mode effect analysis (FMEA) tools. Plackett–Burma...
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#2Mohammed AqeelH-Index: 1
Last. Indrajeet D. Gonjari (Government College)H-Index: 9
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Abstract A simple, specific and accurate reverse phase liquid chromatographic method was developed for the simultaneous determination of Atorvastatin calcium and Nicotinic acid in tablet dosage forms. The analysis has been performed by using Agilent ZORBAX SB-C18 (150 × 4.6 mm, 3.5 u) and mobile phase containing acetonitrile: distilled water (85:15) at pH 4.5 (adjusted with phosphoric acid). The detection was carried out at 261 nm with a flow rate of 1.0 ml/min. The retention times of Atorvastat...
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AbstractThe objective of this study was to provide quality by design (QbD) approach for development of suspension type nasal spray products. Quality target product profile (QTPP) of test product budesonide nasal suspension (B-NS) was defined and critical quality attributes (CQAs) were identified. Critical formulation, process and delivery device variables were recognized. Risk assessment was performed by using failure mode and effect analysis (FMEA) methodology. Selected variables were further a...
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Objective: The objective of the present research work was to develop and validate reversed-phase high-performance liquid chromatography (RP-HPLC) method for quantification of flunisolide in nasal spray formulations. Methods: The developed method was validated according to International Conference on Harmonisation (ICH) guideline with respect to system suitability, accuracy, precision, specificity, linearity, and robustness. An isocratic condition of mobile phase comprising phosphate buffer (pH 5...
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