Cutting edge: FasL+ immune cells promote resolution of fibrosis
Abstract
Immune cells, particularly those expressing the ligand of the Fas-death receptor (FasL), e.g. cytotoxic T cells, induce apoptosis in ‘undesirable’ self- and non-self-cells, including lung fibroblasts, thus providing a means of immune surveillance. We aimed to validate this mechanism in resolution of lung fibrosis. In particular, we elucidated whether FasL+ immune cells possess antifibrotic capabilities by induction of FasL-dependent...
Paper Details
Title
Cutting edge: FasL+ immune cells promote resolution of fibrosis
Published Date
May 1, 2015
Journal
Volume
59
Pages
67 - 76
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